基于前处理和液相色谱分析的药物残留检测

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中图分类号：0657；TQ460.7+2 文献标志码：A文章编号：1001-5922（2025）12-0193-05

Drug residue detection based on pretreatment and liquid chromatography analysis

CHENYanqiong，CHENLing （Zhengda Tianqing Pharmaceutical Group Co.，Ltd.，Lianyungang 222O62，Jiangsu China）

Abstract：Inorder torealize thedetection of drug residues in food，amethod fordetecting 8drug residues inbeef was established based on pretreatment and liquid chromatography combined with mass spectrometry.The pretreatment conditions of the method were optimizedand the methodological verification was carried out.The results showed that the extraction solvent should be 90 % acetonitrile water + acetonitrile buffer solution，and the extraction recovery efectof each drug was good without acid pretreatment.At the same time，the linear relationshipof this detection method is good，thecorrelationcoeffcient is more than O.998，the detection limit isO.O2～0.O9 μg/kg，and the recovery rate is 86.5%～ .112.3% . In summary， based on the optimized pretreatment conditions， the method has good sensitivity，accuracy and precision，which can meet the needs of drug residue detection in food.

Key words ： drug residues;liquid chromatography;acetonitrile;detection limit;recovery rate

随着食品安全问题日益严峻，食品中的药物残留作为一种潜在健康风险因素，对其进行监管和控制非常重要。（剩余6200字）