基于液相色谱法串联质谱联用的化学毒品快速检测方法

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中图分类号：0657.7；TQ086.5 文献标志码：A 文章编号：1001-5922（2025）12-0189-04

A rapid detection method for chemical drugs based on liquid chromatography tandem mass spectrometry

MA Kai （Guizhou Police College，Guiyang 55000o，China）

Abstract： Aiming at the problems of long detection period，poor timeliness，low precision and accuracyof traditional chemical drug detection methods insewage，a magnetic solid phase extraction-high performance liquid chromatography-tandem massspectrometry was constructed to detect chemical drugs insewage.Firstly，the magnetic solid phase extraction conditions were optimized，and then the magnetic solid phase extraction-high performance liquid chromatography-tandem mass spectrometry method was verified.The results showed that when the magnetic solid phase extraction conditions were as folows：the volume of extraction solvent was 40O mL，the amount of magnetic adsorbent was 2OO mg，the eluent was 0.1% formic acid-methanol solution，and the amount of eluent was 8 mL，the correlation R2 between the target chemical drug and the standard curve exceeded O.99.The detection limit and quantitative limit of fentanyl and cocaine were 0.5ng/L and 0.1ng/L ，respectively. The detection limit and quantitative limit of methamphetamine，ketamine and morphine were 0.025ng/L and 0.1ng/L ，respectively. It showed good precision （RSD ⩽3% ） and accuracy （recovery 94%～ 101% ）

Key Words：sewage detection;drug testing;liquid chromatography; magnetic solid-phase extraction;tandem mass spectrometry

通过对城市各个区域污水的检测分析，可以实时、准确地掌握毒品在不同区域的滥用情况，绘制出详细的毒情地图，帮助禁毒部门及时发现毒情热点区域，提前做好预防和管控工作。（剩余5265字）