面向农药残留的多残基液相质谱快速筛查方法应用研究

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中图分类号：TS207.3 文献标志码：A 文章编号：1674-0270（2025）35-0044-04

Abstract：Toenhance the rapid detection levelof pesticideresidues in food，this paper establishedamulti-residue screening method based on liquid chromatography-mass spectrometry （LC-MS）. Using the AB SCIEX 5500+ platform and an mproved QuEChERS pretreatment，350 kinds of pesticides canbe covered in a single injection. After optimizing the chromatographic and mass spectrometric conditions，the method detection limit（MDL） is 0.05～0.5 μg/kg ， with a recovery rate of 85% 2 105% and a relative standard deviation of less than 12% ， meeting international standards. When applied to market and agricultural spot-check samples，the results showed that the detection rate of chlorpyrifos in spinach was 42.6% ， with leafy vegetables having the highest risk and grains having relatively low overall residues. Organophosphates and neonicotinoids were the main sources of risk.This method is highly sensitive， has a large throughput，and is highlyeficient，making itsuitable forlarge-scale regulatory testing and providing technical support for food safety risk assessment and decision-making.

Key Words： pesticide residues; liquid chromatography-mass spectrometry; multi-residue screening; food safety

农药残留会对公众健康构成威胁，并影响农产品的国际市场合规性，已成为全球食品安全的重要问题。（剩余4667字）