鼻导管表面改性抗菌润滑材料制备及性能分析和应用

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中图分类号：TH77； TQ427.2+6 文献标志码：A文章编号：1001-5922（2026）1-0161-04

Abstract：A novel preparation method forlubricating andantibacterial catheters was proposed.First，thecomprehensive performance of the prepared lubricatingandantibacterial catheters was tested，andthen the clinical aplication efctof thecatheters wasanalyzed.Theresults showedthatthe watercontactangleof thelubricatingand antibacterial catheter was 32∘ . After ultrasonic treatment for 3O minutes，the water contact angle remained basically unchanged;after 15O reciprocating friction cycles on a friction and wear tester，the friction coefficient was consistently maintained at around O.O4;the growth rate of L929 cells on the catheter exceeded 100% ;the bacteriostatic rate against Escherichia coli and Staphylococcus aureus was over 98% ，demonstrating excellent comprehensive performance.When applied clinically as nasal catheters ，the effective rate of patient treatment reached 98% ，and the incidence of adverse reactions was only 6% .The patients’ comfort and tolerance were significantly higher than those using ordinary catheters，indicating a favorable clinical application effect.

KeyWords：PVC conduit;surface modification;lubrication performance ;antibacterial performance;clinicalapplication

传统鼻导管多为不具备抗菌作用的普通医用导管，在使用的过程中，易因摩擦系数过大引发鼻损伤，影响患者的佩戴舒适度；还可能因为细菌感染，给患者的身体健康带来一些不好的影响。（剩余5985字）