吸入粉雾剂中难溶药物分散体制备优化与性能提升研究

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中图分类号：TQ460.6 文献标志码：A文章编号：1001-5922（2026）1-0155-04

Abstract：Aiming at the problem of poor solubility of traditional fluticasone propionate powder，a novel method for preparing fluticasone propionate powder dispersion using the supercritical CO2 anti-solvent process was proposed. First，the supercritical fluid processwasoptimized intheexperiment，and then the solubilityof the fluticasone propionate powder dispersion prepared by theoptimized process was investigated.The experimental results showed that when the ratio of solvent methanol to dichloromethane was 3：3 ，the dosage of hydroxypropyl methylcellulose was 30% ，the stirring speed was 800r/min ，the temperature was 45‰ ，and the pressure was 20MPa ，the prepared fluticasone propionate powder dispersion reached dissolution equilibrium rapidly in about 1O min，with a cumulative dissolution rate as high as 82%. It exhibited excellent dissolution effect and good dispersibility.

Key words：inhalation of powder mist agent;dissolution rate ;dispersion performance;supercritical fluid;process optimization

在医疗领域中，吸入粉雾剂凭借其独特的给药方式，在呼吸系统疾病治疗方面占据着重要地位。（剩余4633字）