老年阻塞性睡眠呼吸暂停低通气综合征糖尿病视网膜病变与睡眠质量关系

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Relationship Between Diabetic Retinopathy and Sleep Quality in Elderly Patients with Obstructive Sleep Apnea-Hypopnea Syndrome

HUANG Lei，WU LiCorresponding author，ZENG Xiang，FU Zhihe （Department of Ophthalmology，Xiamen Kehong Eye Hospitall，Fujian Province，Xiamen 36loo6，Chin

AbstractObjective：Toexploretherelationshipbetweeretinopathyand sleepqualityinelderlypatientswithobstructive sleep apnea-hypopnea syndrome（OSAHS）.Methods：A totalof100 elderly OSAHS patients with diabetic retinopathy（DR）admited to Xiamen KeHong Ophthalmology Hospitalfrom May2023 to May2O24 were retrospectivelyanalyzed.The patientswere divided intoanobservationgroup（52cases with sleepdisorders）andacontrol group（48cases withnormal sleep）.Thesleepstatus，central retinal thickness（CRT）and macular microcirculation were compared between the two groups.Pearsoncorelationanalysis was usedtoanalyze therelationshipsbetweenPtsburghSleepQualityIndex（PSQI）scoresandCRT，aswellasmacularmicrocirculationparameters.Results：There werenosignificant diferences inparafoveal vessel density（VD）andfoveal avascular zone（FAZ） area between the two groups（ P>0.05 ）. However，the observation group showed significantly shorter total sleep time，lower macular foveal VD and a lower FAZ morphological index compared to the control group（ P<0.05 ）. The number of awakenings，PSQI score，CRT and FAZ circumference were significantly higher in the observation group（ P<0.05 ）. Pearson correlation analysis showed that PSQI score was negatively correlated with macular foveal VDand the FAZ morphological index（ P<0.05 ），and positively correlated with CRT and FAZ circumference（ P<0.05 ）. Conclusion ：The sleep quality in elderly patients with OSAHS and DR is correlated with CRTand macular microcirculation.The sleepqualityof patients may affect the degreeof retinopathy.

KeywordsObstructive sleepapnea-hypopneasyndrome；Diabeticretinopathy；Sleepquality；Retinal thickness；Elderlypa-tients；Macular fovea； Vascular density； Relationship analysis

中图分类号：R774.1;R338.63 文献标识码：A doi：10.3969/j.issn.2095-7130.2025.07.011

阻塞性睡眠呼吸暂停低通气综合征（OSAHS）是一种睡觉时呼吸反复受阻的疾病，患者伴有夜间睡眠打鼾、呼吸暂停、白天嗜睡、记忆力减退等症状[1]。（剩余4872字）