血清CXCL16、sCD40L与缺血性卒中后患者认知功能障碍及睡眠质量的相关性

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Correlation between Serum CXCL16 and sCD40L with Cognitive Impairment andSleepQualityinPatientswithIschemicStroke

WU Lin

（Neurological Medicine Center，The Second Hospital，University of South China，Hengyang 42100l，China）

AbstractObjective：To explore thecorrelation betweenserum CXC chemokine ligand16（CXCL16），soluble CD4O ligand （sCD40L），withcognitiveimpairmentandsleepquaityofpatients withischemicstroke（IS）.Methods：Atotalof92patintswith ISadmitedtotheSecond Hospital，UniversityofSouthChinafromJanuaryO24toJanuary2O25wererecruited.Theircognitive functionandsleepqualitywere assessedusing the Montreal Cognitive Assessment（MoCA）and Pitsburgh Sleep Quality Index （PSQI），respectively. Patients were divided into a cognitive normal group（MoCA score≥26， n=62 ）and a cognitive impairment group（ MoCA score <26，n=30 ）based on MoCA scores. Clinical data were collected and serum CXCL16 and sCD4OL levels were measured.MultivariateloisticregresionanalysissusedtoidentifyiskfactorsafecingtheocurrenceofIS-iducdcgitive impairment，and Spearmancorelation analysis wasemployed to examine therelationshipbetweenserum CXCL16，sCD4OLlevels and sleepqualityofthosepatients.Results：Theage，admision National Institutesof Health Stroke Scale（NIHSS）score，erum CXCL16，sCD4Llevels，andPSQIscoresweresignificantlyhigher inthecognitive impairment groupcomparedtothecognitive normal group（ P<0.05 ）.No significant diffrences were observed in gender，smoking history，alcohol consumption history，comorbidities（hypertension，dabetes，hyperlipidemia），locatioadtypeofISbodyassidex，andlvelsofTotalcholesrol， highdensitylipoproteincholesterol（HDL-C），lowdensitylipoproteincholesterol（LDL-C），itebloodcellcount（WBC），platelet count（PLT） between the two groups（ P>0.05 ）. Multivariate logistic regression analysis indicated that PSQI scores and serum CXCL16，sCDLlevelswereriskfactors forcognitive impairment afterIS.Spearmancorelationanalysisrevealedapositivecorrelation between serum CXCL16 and sCD40L levels with PSQI scores in IS-induced cognitive impairment patients（ r=0 .680， 0.721，P<0.05 ）.Conclusion：Serum CXCL16 and sCD4OL are risk factors for IS-induced cognitive impairment and are closely relatedtosleepqualityinthepatients.Theymaysereasbiomarkersforpredicting theoccurrenceof IS-ducedcognitiveimpairment and assessing patients' sleep quality.

KeywordsIschemic stroke； Cognitive impairment;Serum CXC chemokine ligand 16；Soluble CD40 ligand； Sleepquality

缺血性卒中（IschemicStroke，IS）是一种由多种因素引起的缺血性脑血管疾病，其发病率呈不断递增趋势。（剩余6701字）