超高效液相色谱-串联质谱法测定广式凉茶中4种非法添加药物

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Determination of Four Illegal Added Drugs in Cantonese Herbal Tea byUPLC-MS/MS

ZHENG Lisi'， YAN Liyi'， CHENMiaolan1， DONG Qiuxia1，RONG Jinqing1， YANG Fang （1.Jiangmen Food Inspection Institute， Jiangmen 529ooo， China; 2.Jiangmen Customs District Technology Center， Jiangmen 5290o0， China）

Abstract：Establish an analytical method for the determination of ilegally added ibuprofen，loratadine， aminopyrine，and dexamethasone acetate in Cantonese herbal tea by UPLC-MS/MS.After ultrasonic extraction with methanol， the sample was filtered through a 0.22μm microporous membrane. The multiple reaction monitoring mode， positive and negative ion mode scanning，and external standard method were used for quantitative detection.The results show that the four tested compounds have good linear relationships within the corresponding linear ranges， and their correlation coefficients are all greater than O.999. The detection limit was to 151.50μg⋅kg-1 The recovery rate was 86.8% to 101.9% ，and the relative standard deviation was 0.29% to 0.94% . This method is simple， fast，and highlysensitive，suitable for the determinationof ibuprofen，loratadin，aminopyrine，and dexamethasone acetate in Cantonese herbal tea.

Keywords： Cantonese herbal tea; illegal addition; drugs

广式凉茶文化历史悠久，因具有祛火除湿、生津止渴、清热解毒等功效，深受人们喜爱。（剩余3661字）