基于液相色谱-串联质谱法测定动物性食品中喹诺酮类药物残留

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Abstract： Based on the National Food Safety Standard Determination of Tetracyclines，Sulfonamides and Quinolones Residues in Animal Derived Foods by Liquid Chromatography-Tandem Mass Spectrometry （GB 31658.17—2021），a liquid chromatography-tandem mass spectrometry method suitable for quinolone drug residues inanimal foods is conducted，and systematic methodological validation iscarried out.The results showthat there is a good linear relationship between the target drugs in the concentration range of to 40ng⋅mL-1 （the correlation coefficient is greater than O.99）， the recovery rate of spiked drugs is between 69.9% and 106.6% ，the relative standard deviation is less than 15% ，the quantification limit meet the requirement of 10μg⋅kg-1 .This indicates that the method has good accuracyand reliability，and can be efectivelyapplied to the daily detection of quinolone drug residues in animal foods.

Keywords： animal foods; drug residue; liquid chromatography-tandem mass spectrometry

在当代畜禽养殖业规模化发展的背景下，喹诺酮类抗菌药物作为兽用防治药剂得到了广泛应用。（剩余4450字）