超高效液相色谱-串联质谱法快速测定大米中磺酰脲类和酰胺类除草剂残留

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Rapid Determination of Sulfonylurea and Amide Herbicides Residuesin Riceby UPLC-MS/MS

CHENXiaojian，ZHUWanchao，LIUYixi，CHIJinlin （Ruijin Comprehensive Inspection and Testing Center， Ruijin 3425oo， China）

Abstract： Objective： To develop a rapid method for the simultaneous determination of 49 sulfonylurea and amide herbicides residues in rice byoptimizing the QuEChERS method combined with Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry （UPLC-MS-MS）. Method： The sample was extracted by acidified ACN， purified by modified QuEChERS method and simultaneously determined by UPLC-MS-MS equipped with electric spray ion source.The matrix curve was quantified by extermal standard method.Result： The linear relationship of 49 herbicides was good within the range of 1ng⋅mL-1 to 100ng⋅mL-1 ，with a correlation coefficient （R） of 0.993 5 to 0.999 9， a limit of detection of 0.003μg⋅kg-1 to 0.160μg⋅kg-1 ，a limit of quantification of 0.010μg⋅kg-1 to 0.540μg⋅kg-1 ， an average recovery rate of 62.7% to 109.1% ，and a relative standard deviation of 0.6% to 9.9% Conclusion： This method issensitive，accurate，and stable，and can meet the detection requirements for 49 types of sulfonylurea and amide herbicides residuesin rice.

Keywords： Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry （UPLC-MS/MS）; rice; sulfonylurea; amide; herbicide residue

水稻是我国三大主粮之一，对我国粮食供应和社会稳定影响极大[]。（剩余5217字）