慢性乙型病毒性肝炎采用恩替卡韦标准化治疗效果分析

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Abstract：Objective：To investigate the effectof entecavir standardized treatment in patients with chronic viral hepatitis B.Methods： A totalof 40 patients with chronic viral hepatitisBadmited to the Bengbu Hospital of Shanghai General Hospital from April2019 toApril2O24 were selectedand divided intothecontrol groupand theexperimental group with 20 cases ineach group by dice method.Thecontrol group received conventional treatment with lamivudine and the experimental group received enticavir standardized treatment. The therapeutic efect of the two groups was compared.Results：The total efectiverateof the experimental group was significantly higherthanthatof the control group， P<0.05 ; The levels of aspartate aminotransferase （AST）and alanine aminotransferase （ALT） in the experimental were significantly lower than those in the control group， P<0.05 .The negative rate of HBV-DNA and ALT normalizing rate of the experimental group were significantly higher than those of the control group， P<0.05 . There was no significant difference in the incidence of adverse reactions between the two groups （P>0.05） . Conclusion： The entecavir standardized treatmentcanimprovethe liver function indexof patients withchronic hepatitisB，and increasethe negative rate of HBV-DNA and ALT normalization rate， with better clinical effcacy and safety.

Keywords： chronic hepatitisB;entecavir; standardized treatment

0 引言

慢性乙型病毒性肝炎（慢性乙肝，ChronicHepatitisB，CHB）作为一项重大的全球公共卫生挑战，不仅严重影响患者的生活质量，还可能逐步发展为肝硬化甚至肝细胞癌，给患者个体及社会带来巨大的疾病负担[]。（剩余3431字）