基于肝-肠-脑轴探讨运动干预对非酒精性脂肪性肝病的作用机制与发展前景

【中图分类号】G80-05 【文献标识码】A 【文章编号】2095-2813（2025）27-0010-04

[Abstract] Non-alcoholic fatty liver disease （NAFLD），has become the most prevalent chronic liver disease globally，and its association with cognitive impairment，dementia，and other brain health isues is receiving increasingattention.In recent years，the liver-gut-brainaxis has emerged as acentral pathophysiological framework，revealing the key mechanisms bywhichgut microbiotadysbiosis，livermetabolicdisorders，systemicinflmmation，andneuroinflammation colectively constitute NAFLD-related encephalopathy. As a first-line treatment strategy for NAFLD，exercise intervention has benefits farbeyond improving intrahepatic lipid deposition， encompasing multi-target regulationof the "liver-gut-brain axis"to exert protective efects on the brain.It summarizes the evidence chain that exercise improves cognitive function through multiple pathways such as reshaping the gut microbiome， enhancing intestinal barier integrity，reducing liver inflammationand insulinresistance，and lowering peripheral and central inflammation levels.Itlooks forward tothefutureclinicaltranslation prospectsandchallenges inthisfeld，includingthedevelopment of precise exercise prescriptions，the aplication of multi omics techniques，and the necesstyof large-scale long-term randomizedcontrolled trials，providingaimportant theoreticalbasisanddirectional guidancefor non-pharmacological intervention of cardiovascular and cerebrovascular comorbidities inNAFLD patients.

[Keywords] Non-alcoholicfaty liver disease; Cognitive dysfunction; Exercise intervention; Livergut-brainaxis; Gutmicrobiome;Neuroinflammation

非酒精性脂肪性肝病（Non-alcoholicfattyliverdisease，NAFLD）已成为全球最常见的慢性肝病，其患病率呈逐年上升趋势，其疾病谱系可进展为肝炎、肝纤维化乃至肝硬化，带来沉重的健康负担。（剩余5595字）