龙岩地区慢性肾脏病患者合并阻塞性睡眠呼吸障碍的特点分析

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AbstractObjective：Toanalyze thecharacteristics ofcomorbidobstructive sleepapnea hypopnea syndrome（OSAHS）inchronic kidneydisease（CKD）patients in Longyanregion.Methods：A totalof 120 patients with CKDdiagnosedas OSAHS through polysomnography（PSG）andadmitedtoLongyanPeople'sHospitalinFujianProvincefromJune2O23toNovember2O24 wereselected as the study subjects. They were divided into mild（ stages 1 to 2，n=45 ），moderate（ stages 3 to 4，n=48 ），and end-stage renal disease（ESRD；stage 5，n=27 ）groups based on estimated glomerular filtration rate（eGFR）.Colect demographic data，physical examinationindicators，aboratoryindicatorshemoglobin（Hb）]，SGindicatorssleepapeahypopneaidex（AH），lowstblood oxygen saturation（ LSpO2 ），percentage of total sleep time with Sp02 below 90% （ CI90% ）] from each group of patients，analyze thecorelationbetween CKDstage，HblevelandPSGinicatorlevelinthetreegroupsofpatients，andthecorelationbetwen PSG indicatorsand weightgain duringdialysis treatmentintheESRD groupof patients.Results：TheBMI，weight，AHI，and （20 Cl90% levels of the three groups of patients were compared as mild group < moderate group < ESRD group. The Hb and ΠLSaO2 （204号 levels of the three groups were compared as mild group > moderate group > ESRD group，and the diferences were statistically significant（ P<0.05 ）； The CKD staging of the three groups of patients was positively correlated with AHI and CT90% ，and negatively correlated with lSa02 ，with statistical significance（ P<0.05 ）.Hb was negatively correlated with AHI and CI90% ，and positively correlated with LSaO2 ， with statistical significance（ P<0.05， ）；The BMI and weight gain of ESRD group patients were positively correlated with AHI and CT90% ，and negatively correlated with LSaO2 ，with statistical significance（ P<0.05 ）. Conclusion：CKDpatients inLongyan region frequently present with varying severityof OSAHS.Thecondition correlates with CKD stage，BMI，interdialytic weight gain，and Hb levels.

KeywordsChronic kidney disease；Obstructive sleep apnea syndrome；Renal impairment； Sleep disorders；relevance;Dialysis; Interdialytic weight gain; Polysomnography（ PSG）

中图分类号： R334+.1 ;R338.63 文献标识码：A doi：10.3969/j.issn.2095-7130.2025.05.008

慢性肾脏病（Chronic KidneyDiseases，CKD）是由于患者肾脏结构或功能损伤持续3个月以上，对人体健康造成严重不良影响的一种疾病[1]。（剩余6432字）