基于85例病例分析阻塞性睡眠呼吸暂停患者舌诊特征与相关疾病关联

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＼AbstractObjective：To investigate thecharacteristicsof Traditional Chinese Medicine（TCM）syndromes inobstructive sleep apnea hypopnea syndrome（OSAHS）patients by analyzing correlations between polysomnography（PSG）parameters and tongue features，therebyderivingOSAHS-relatedriskfactors/diseasesandexploringcausal relationships.Methods：Aretrospectiveanaly sis was conducted on85cases of OSAHS.PSG parameters（e.g.，apnea-hypopnea indexAHI]，lowest pulse oxygensaturation （24 ⌊LpSO2 ]，respiratorydisturbance indexRDI]）and tongue characteristics（e.g，tongue morphology，fisures，coating color）were documented.Dual-entryExcelrecordsunderwentlogisticregressontoanalyzePSG-tonguefeaturecorrelations.TCMsydrome paterns and tongue characteristics were summarized to identifyriskfactors/diseases.Using GWAS public databases and two-sample bidirectional Mendelian randomization（MR） analysis in R，P -values for OSAHS-risk factor/disease associations were calculated（ significance ： P<0.05 ）.Results：AHI significantly correlated with tongue size，fissures，coating color，and interarytenoid edema.Enlargedtongue，absenceoffisures，yelowcoating，andabsenceofinterarytenoidedemaincreasedsevere OSAHS risk. Enlarged tongue and middle/lower burner coating distribution elevated severe LpSO2 risk， while enlarged tongue，middle/lowerbumercoating，andabsentinterartenoidedemaincreasedsevereRDIrisk.Asthma，obesityheartfailure，andgastroesohgeal reflux showedcausalrelationshipswithOSAHS，withasthmaandobesitydemonstrating bidirectionalcausality.Conclusion：Tongue diagnosis provides criticalevidence fordeterminingOSAHSsydromepattrnsandseverityofering sreeningvalue for OSAHS-relatedrisk factors/diseases.This studyfurnishes evidence-based supportformodern medical applications of tongue diagnosis and proposes a novel diagnostic model integrating tongue examination with contemporary medical techniques.

KeywordsObstructive sleep apnea；Polysomnography（PSG）；Tongue diagnosis； Traditional Chinese Medicine syndromepattern；Diseaseriskfactors/coelations；Causalrelationship；DoublesamplebidirectionalMendelianrandomizationanalysis；Evidence-based support

中图分类号：R364.4;R338.63 文献标识码：A doi：10.3969/j.issn.2095-7130.2025.05.004

阻塞性睡眠呼吸暂停低通气综合征（ObstructiveSleep Apnea Hypopnea Syndrome，OSAHS）是一种常见的睡眠呼吸障碍疾病。（剩余7605字）