百合地黄汤加味治疗对老年精神障碍失眠患者失眠严重程度的影响

打开文本图片集

Impacts of Modified BaiheDihuang Decoctionon the Severity of Insomnia in Elderly Patients with Mental

TIAN Mingxing

（TheFifth People's Hospital ofZibo City，Zibo 25510O，China）

AbstractObjective：Investigationintotheimpacts of modified Baihe DihuangDecoctionontheseverityof insomniain elderly patientswithmentaldisorders.Methods：Atotalof9OgeratricpatientsdiagnosedwithmentaldisordersandinsomniaintheFifth People'sHospitalof Zibo CityfromOctober 2O22 to October2024 were selected assubjects forthisstudy.The patients wererandomized intotwo groups with45each，using theredand blueballmethod.Thecontrol groupreceivedstandard therapy，whereas theobservationgroup wasadministeredamodified versionoftheBaiheDihuang Decoction.The studycompared the pre-and posttreatmentsleepqualityandrelatedserum biomarkers betweenthetwogroups.Results：Folowing treatment，theISIand SDQ scores in the observation group were diminished compared to the control group（ P<0.05 ）.After intervention，the MT levels，serotonin，gamma-aminobutyricacid，andotherbiomarkersintheobservationgroupwerereducedcompared tothecontrolgroup（ P< 0.05）.Conclusion：ModifiedBaihe Dihuang Decoctioncansignificantly improve insomnia symptoms，reduce the levelsof serum 5-hydroxytryptamineandgamma-aminobutyricacid，andincreasethelevelofsrummelatonninelderlypatientswithmntaldisorders and insomnia.

KeywordsBaihe Dihuang Decoction;Elderly mental disorders；Severityof insomnia；Melatonin levels；Serotonin； γ -GABA; Sleep disorders； Insomnia

中图分类号：R338.63;R256.23 文献标识码：A doi：10.3969/j. issn.2095-7130.2025.02.031

失眠与焦虑、抑郁等精神症状相互交织，形成恶性循环，进一步加重老年精神障碍患者的病情[1]传统的治疗方法多采用西药镇静催眠药物，虽能在一定程度上缓解失眠症状，但长期使用往往伴随着诸多不良反应，如药物依赖性、认知功能损害、共济失调等，增加了老年患者健康风险[2]。（剩余4830字）