分析神经节苷脂钠联合高压氧对颅脑损伤术后昏迷患者早期促醒效果及睡眠质量的影响

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Analysis of the Early Wake-Up Efect and Sleep Quality Improvement of Ganglioside Sodium Combined with Hyperbaric Oxygen on Patients with Coma after Craniocerebral Injury Surgery

（Huai'an 82nd Hospital，Huai'an 223600，China）

AbstractObjective：Toinvestigate theefectSof ganglioside（GA）combined withhyperbaricoxygen（HBO）onearlyawakening anditsimpactsonslpqualityinpatientswithcomaaftercraniocerebralinjurysurgery.Methods：Atotalof89postoperativecomatosepatients with craniocerebral braininjuryadmited tothe Neurosurgery DepartmentofHuai'an 82nd HospitalfromJanuary 2019 to January 2O24 were selected as the study subjects.They were randomly divided into a control group（ n=42 ）and an observation group（ n=47 ）using a random number table method. The control group received routine postoperative management and GA treatment，while theobservation groupreceived HBOandGA treatment.The Pitsburgh Sleep Quality Index（PSQI）was used to comparethechanges insleepqualitybeforeandafter interventionbetweentwogroups.Thechangesinbloodflowvelocity，awakeningtime，and neurologicalfunctionindicatorsbetweenthetwo groups werecompared.The incidenceof adverseevents wasalso comparedbetweenthetwo groups.Results：After treatment，theawakening timeof theobservationgroup wassignificantlyshorter thanthatof thecontrolgroup.Theintracranial midlecerebralartery（MCA）bloodflowvelocityoftheobservation grouppatients wassignificantlylowerthanthatofthecontrolgroup.ThePSQIscoresof theobservationgrouppatientsweresignificantlylower thanthoseofthecontrolgroup.Thebrain-derivedneurotrophicfactor（BDNF）levelsoftheobservationgrouppatients weresignificantlyhigherthanthoseofthecontrolgroup，andthecerebrospinalfluidnorepinephrine（NE）levelsweresignificantlylowerthan thoseof thecontrol group.Theincidenceofadverseeventsintheobservationgroupwassignificantlylower than thatof hecontrol group，and the differences between the two groups were statistically significant（ P<0.05 ）. Conclusion： GA combined with HBO treatmentforcomatosepatientsaftercraniocerebralbraininjurysurgerycansignificantlyshortentheawakeningtime，improve sleepquality，promoteneurological functionrepair，and hasgoodsafety.Itisworthyof clinical promotionandapplication.

KeywordsComa;Brain injury;； Ganglioside; Hyperbaric oxygen；Awakening; Slpquality；Adverse events；Neurological function

中图分类号：R651.1+5;R338.63 文献标识码：A doi：10.3969/j. issn.2095 -7130.2025.02.013颅脑损伤是临床常见的严重疾病，其术后昏迷 状态对患者预后具有重要影响[1]。（剩余4631字）