右佐匹克隆辅助治疗精神分裂症伴睡眠障碍的临床疗效及不良反应发生率影响分析

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Clinical Efficacy and Adverse Reaction Rate Analysis of Eszopiclone as Adjuvant Therapy for Schizophrenia Combined with Sleep Disorders

LI Li，GAO Zhongde，CHU Sailei （Yantai Mental RehabilitationHospital，Yantai2652OO，China）

AbstractObjective：Toanalyzetheclinical eficacyandsafety ofeszopiclone as anadjuvanttherapyinthe treatmentof schizophrenia combinedwithslepdisorders.Methods：Atotalof7Opatients diagnosedwith schizophreniacombinedwith sleepdisorders inourhospitalfromJanuary2O19toAugust2O23wereselectedastheobservationsubjects.Theywererandomlydivided into a control group（ n=35 ）and an observation group（ n=35 ） using the random number table method. The control group received conventionaltreatment，hiletheobservationgroupreceivedconventionaltreatmentcombinedwitheszopicloneasanadjunctive treatment.Thedifferencesindiseasecontroleficacy，dversereactionrate，sleepqualityscores，positiveandnegativesdrome scale scores betweenthetwo groups were compared.Results：Theeficacyrateof diseasecontrolintheobservation group was （204号 94.29% ，which was significantly higher than that of the control group（ 74.29% ）. The incidence of adverse reactions was lower， andthe sleepqualityscores were significantlylower thanthoseof thecontrol group.Thescores of positivescale，negativescale， andgenral psychopathologyscaleweresignificantlylowerthanthoseof thecontrolgroup，andthediferenceswerestatisticaly significant （ P<0.05 ）. Conclusion：The adjunctive treatment of eszopiclone in the treatment of schizophrenia combined with sleep disorders has a definite clinical effect.

KeywordsEszopiclone； Schizophrenia；Sleep disorder；Eficacy； Safety中图分类号：R338.63;R749.3 文献标识码：A doi：10.3969/j. issn.2095 -7130.2025.02.017

精神分裂症（Schizophrenia）是一种严重的精神疾病，该病也叫作思觉失调症、调弦症、统合失调症等，其特征是思维、情感和行为之间的不协调[1]。（剩余2727字）