重复经颅磁刺激联合右佐匹克隆对帕金森睡眠障碍患者睡眠质量的影响
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Effects of Repetitive Transcranial Magnetic Stimulation Combined with Eszopiclone onSleepQualityinPatientswith Parkinson'sDiseaseand SleepDisorders
LI Jing，LI Ruixia
（DepartmentofNeurology，TheAfliated Hospitalof Nanjing UniversityMedical School，Suzhou215ooo，China）
AbstractObjective：Toivestigatetheefectsofrepetitive transcranialmagneticstimulationcombinedwith eszopicloneonsleep qualityandneurotransmiterlevelsinpatientswithParkinson'sslepdisorders.Methods：Atotalof63patientswithParkinson's diseaseandslpdisodersadmittedtotheAflatedHospitalofNanjing UniversityMedicalScholfromJune2O22toJune2024 wereselectedas theresearch subjects.Theywererandomlydividedintoacontrolgroup（3Ocases）andanobservationgroup（33 cases）acording toarandomnumbertable method.Thecontrolgroupreceived eszopiclonetreatment，whiletheobservationgroup receivedrepetitivetranscranialmagneticstimulationtherapyandeszopiclone.Thetreatmentperiodwas4weks.ThePisburgh SleepQuality Index（PSQI）was usedtocompare thediferences insleepqualitybetwen two groups.The Insomnia Severity Index （ISI）wasused to evaluate thedegreeof insomnia beforeandafter treatmentinthetwo groups.Theself-made Parkinson'sdisease sleepscalewasusedtocomparethe symptomimprovement efectsof thetwo groups，andtheincidence ofadverse events wascompared.Results：Aftertreatment，the PSQI scoresand ISIscoresofthe observation groupwere significantlylowerthanthoseof the controlgroup，andthe Parkinson's disease sleepscale scores were higherthan thoseofthecontrol group.The diferences betwen the two groups were statistically significant（ P<0.05 ）；There were no statistically significant differences in the incidence of adverse events between the two groups（ P>0.05 ）. Conclusion： Repetitive transcranial magnetic stimulation combined with eszopiclonecanefectively improvethesleepqualityandalleviateinsomniasymptoms inpatientswitharkinson'sdiseaseandsleepdisorders，and is worthy of clinical promotion and application.
KeywordsParkinson's disease；Sleepdisorders；Repetitive transcranial magnetic stimulation；Eszopiclone；Sleepquality 中图分类号：R338.63 文献标识码：A doi：10.3969/j. issn.2095-7130.2025.02.014
帕金森病的临床表现包括不自主的颤抖、行动迟缓等标志性运动症状，同时还可能引发睡眠障碍等非运动症状，这些症状严重干扰患者的日常生活，降低其生命质量[1]。（剩余5790字）