冬瓜皮水提物抗氧化活性及降尿酸作用研究

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Study on the Antioxidant Activity and Uric Acid-Lowering EffectofWaxGourdPeel WaterExtract

TONG Rong， QIN Si* （HunanAgriculturalUniversity，Changsha41O128，China）

Abstract： Objective： To study the antioxidant activity and uric acid-lowering effect of wax gourd peel water extract.Method： The scavenging ability of wax gourd peel water extract on DPPH free radicals and ABTs+ free radicals and the inhibitory ability on Xanthine oxidase （XOD）activity were evaluated by in vitro experiments.The uric acid-lowering effect of wax gourd peel water extract was evaluated by establishing a hyperuricemia HepG2 cell model. Result： The half-inhibitory concentrations of wax gourd peel water extract on DPPH，ABTS*，and XOD were 1.04， 0.96， and 0.80mg⋅mL-1 ，respectively. In hyperuricemia HepG2 cells， wax gourd peel water extract could effectively reduce XOD activity （  p  < 0 . 0 1  ）. Conclusion： Wax gourd peel water extract has antioxidant and uric acidlowering abilities，which providesan important theoretical basis for the development of functional foods and the prevention of chronic diseases.

Keywords： wax gourd peel; hyperuricemia; antioxidant; uric acid-lowering

高尿酸血症（Hyperuricemia，HUA）是临床上常见的慢性代谢性疾病，其发病机制主要涉及嘌呤代谢紊乱与尿酸排泄功能异常，进而引发尿酸生成过多或排泄不足，从而表现出血清尿酸值偏高[1]。（剩余4932字）