质子泵抑制剂在溃疡性结肠炎临床应用中的研究进展

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[Abstract]Ulcerative colitis （UC） is a chronic inflammatory bowel disease， with its pathogenesis closely related to multiple factors such as gut microbiota imbalance，abnormal intestinal mucosal immune regulation， genetics，and environment.Proton pump inhibitors （PPIs） are currently the most widely used acid suppressants，

but their long-term use may have profound efects on the gut microbiota and immune system.Long-term use of PPIs may influence the risk of developing UC and the progression of the disease through mechanisms such as altering the composition of gut microbiota，disrupting intestinal barrier function，and interfering with immune regulation.Thisarticle discusses the clinical epidemiological evidencerelatedtoPPIsand UC，explores potential mechanisms，and provides clinical application recommendations，aiming to ofer a basis for the rational use of PPIs in UC patients.

[KeyWords] Proton pump inhibitorsUlcerative colitisGut microbiotaIntestinal barrierImmune regulation

First-author'saddress：GraduateSchoolof XinjiangMedical University，Urumqi 83oo17，China doi：10.3969/j.issn.1674-4985.2026.08.041

溃疡性结肠炎（ulcerativecolitis，UC）是一种以结肠黏膜慢性炎症为特征的炎症性肠病（inflammatoryboweldisease，IBD），以腹泻、腹痛和黏液脓血便为主要临床特征。（剩余14275字）