3D腹腔镜下结直肠癌根治术的效果及对腹膜微结构、肠黏膜屏障的影响

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[Abstract]Objective： To explore the therapeutic effect 3D laparoscopic radical resection for colorectal cancer and observe the influence this surgical method on the peritoneal microstructure and intestinal mucosal barrier patients.Method： A total 40 patients who underwent 3D laparoscopic radical resection colorectal cancerand wereadmited to Suzhou Xiangcheng People's Hospital from June2O23 to February 2O25 were selected as the observation group，and 4O patients who underwent 2D laparoscopic radical resection colorectal cancer were matched according to 1：l propensity score as the control group.The perioperative indicators，incidence complications，recovery time gastrointestinal function （recovery time bowelsounds，exhaust time and defecation time），peritoneal microstructure indicators and intestinal mucosal barier indicators [serum diamine oxidase （DAO）， D-lactic acid （D-Lac） and endotoxin （ET）] the two groups were compared. Result： The operation time and postoperative hospital stay the observation group wereshorter than those the control group，the intraoperative blood loss was less than that the control group，and the number lymph node dissections was more than that the control group （ P <0.05）. The total incidence postoperative complications in the observation group was significantly lower than that in the control group （ P <0.05）. The recovery time gastrointestinal function in the observation group were significantly earlier than those in the control group P <0.05）. The peritoneal microstructure index scores the observation group were significantly lower than those the control group （ P <0.05）.At12 and 48 hours after the operation，the DAO，D-Lacand ET the observation group were significantly lower than those the control group （ P <0.05）.Conclusion： Compared with 2D laparoscopic radical resection colorectal cancer， 3D laparoscopicradical resection colorectal cancercan beter improve perioperative indicators，reduce the incidence complications，and more efectively control peritoneal microstructure and intestinal mucosal barrier injury.

[KeyWords]3D laparoscopic operation2D laparoscopic operationRadical resection for colorectal cancer Peritoneal microstructureIntestinal mucosal barrier

First-author'saddress： General Surgery Department， Suzhou Xiangcheng People's Hospital， Suzhou 215131， China

doi：10.3969/j.issn.1674-4985.2026.08.028

结直肠癌在胃肠道恶性肿瘤中的占比较高，而且受多方面因素影响，其发病率呈现升高的趋势，因此针对结直肠癌的各方面研究均多见。（剩余5501字）