玛巴洛沙韦治疗儿童乙型流行性感冒的临床效果

打开文本图片集

[Abstract]Objective：To evaluate the clinical value Baloxavir Marboxil in the treatment pediatric influenza B.Method： Atotal 2OO children with influenzaBadmited to the from January to December 2O24 were selected andrandomlydivided into control group and experimental groupat aratio 1：1，with10Ocases ineach group.Thecontrol group was treated with Oseltamivir Phosphate，whilethe experimental group was treated with Baloxavir Marboxil.The differences in complete fever reduction time，blood routine indicators [WBC， neutrophil count （NEUT），lymphocyte count （LYMP）， monocyte count （MONO）]， CRP， IL-6， natural killer（NK）cells，Tlymphocyte subsets，and the incidence adverse reactions werecompared between the two groups.Result： The experimental group had shorter time to complete defervescence than the control group （ P <0.05）.Five days after medication，the MONO the experimental group was lower than that the control group （ P <0.05）; there were no statistically significant diferences in WBC，NEUT and LYMP between the two groups（ P> 0.05）.Five days after medication，thelevels IL-6and NK cellin the experimental group were lower than those in the control group （ P <0.05）;there wasno statistically significant difference in CRP between the two groups （ P >0.05）. Five days after medication，the levels CD3 †+ CD4 ↓+ ， and CD4+/CD8 + in the experimental group were higher than those in the control group，while CD8 + was lower than that in the control group （ P <0.05）. The incidence adverse reactions in the experimental group was lower than that in the control group （ P <0.05）.

Conclusion： Compared with Oseltamivir Phosphate，Baloxavir Marboxil treatment inchildren with influenza B results in faster temperature normalization，improved inflammatory and immune indicators，andalower incidence adverse reactions.

[KeyWords]Baloxavir MarboxilInfluenzaBChildren Inflammatory responseAdverse reactions

First-author'saddress： Department Pediatrics，the ， 226500，

China

流行性感冒临床主要表现为发热、头痛、乏力及呼吸道症状，常伴全身酸痛等[]。（剩余5766字）