子宫内膜异位症无创生物标志物研究的最新进展

[Abstract]Endometriosis has dual characteristics of chronic inflammation and tumor-like features，and thereisasignificantdelayinitsclinicaldiagnosis.This studyaims toqualitativelyanalyzetherelationshipbetween multiple non-invasive biomarkers and the occurrence of endometriosis by systematically integrating existing literature evidence，inorder to comprehensively evaluate their clinical application potential.This studyadopted the methods of systematic literature review and qualitative integrative analysis，systematicall search databases such as PubMed，Webof Science，and China National Knowledge Infrastructure （CNKI） tocolect observational studies on the association between endometriosis and non-invasive markers in the past five years. Through summarizing， comparing and comprehensively elaborating the core viewpoints，research designs and main conclusions of these literatures，anoverview evaluation is formed.Through literature integration，it was found that glycoproteins， inflammatory cytokines，immune markers，angiogenesis markers，hormones，microRNAs，proteomics，microbiomics， metabolomics，and genomics areabnormally expressed inpatients with endometriosis，closely related to the occurrence and development ofthe disease.This literature review summarizes the potential application valueof these biomarkers，providing areference for the establishmentofan eficient non-invasive diagnostic system in the future.

[Keywords]EndometriosisNon-invasive Biomarkers

子宫内膜异位症是一种慢性炎症性疾病，定义为子宫外存在子宫内膜样组织，引起盆腔疼痛和不孕[]。（剩余11683字）