PTGD结合清肝利胆汤对肝胆湿热证重症急性胆囊炎患者肝功能、炎症因子的影响

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[Abstract]Objective： To explore the effects of percutaneous transhepatic gallbladder drainage （PTGD） combined with Qinggan Lidan Decoction on the liver function and inflammatoryfactors in patients with severe acute cholecystitis with dampness-heat of liverand galbladder syndrome.Method：A total of 2OO patients with severe acute cholecystitis with dampnessheat of liverand galbladder syndrome who were admited to Department of Gastrointestinal and Hepatobiliary Surgery，the Second People's HospitalofFujian Universityof Traditional Chinese Medicine from January 2023 to December 2O24 were grouped by random number table method.The control group （n=1OO） received PTGD treatment， and the observation group （ n =100）was treated with PTGD combined with Qinggan Lidan Decoction.The postoperative recovery conditions，TCM syndromes scores，treatment effect， liver function and inflammatory factors of the two groups were compared.Result： The first exhaust time and the disappearance time of symptoms in the observation group were earlier than those in the control group （ P <0.05）. After

2 weeks of treatment，the scores of various TCM symptoms in the observation group were lower than those of the control group，and the total effective rate of the observation group was higherthan that of the control group （ <0.05）. After 2 weeks of treatment，the levels of TBIL，AST，ALT， WBC， CRP and PCT in the observation group were lower than those in the control group P<0.05） . Conclusion： The application of PTGD combined with Qinggan Lidan Decoction in the treatment of severe acute cholecystitis with dampness-heat of liver and gallbladder syndrome is effective，which canrelieve clinical symptoms，promote postoperative recovery ofpatients，improveliver function and reduceinflammatory reaction.

[KeyWords] Percutaneous transhepatic gallbladder drainage Qinggan Lidan Decoction Severe acute cholecystitisLiver function Inflammatory reaction

First-author's address： Department of Gastrointestinal and Hepatobiliary Surgery，the Second People's Hospital ofFujian Universityof Traditional Chinese Medicine，Fuzhou 35ooo3， China doi ： 10.3969/j.issn.1674-4985.2026.08.002

急性胆囊炎是临床发病率较高的一种急腹症，通常因胆囊管发生梗阻、感染细菌或遭受到化学性刺激等导致，属于急性炎症性病变，临床症状多表现为发热、恶心、右上腹阵发性绞痛，若不及时采取有效治疗，极易发展为重症急性胆囊炎，增加胆囊坏疽、穿孔等并发症发生风险，危及生命安全[]。（剩余5601字）