吲哚胺2，3-双加氧酶在原发性干燥综合征发病机制中的研究进展

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[Abstract]Primary Sjogren's syndrome （pSS） is a chronic autoimmune disease，mainly characterized by exocrine gland dysfunction， with clinical manifestations such as dry mouthanddry eyes.Its pathological mechanism is complexand involves multiple abnormalitiesofthe immune system.Inrecent years，indoleamine 2，3-dioxygenase （IDO），as a key enzyme regulating immune responses， has gradually attracted the atention of researchers.IDO may play a significant role in the pathogenesis of pSS through mechanisms such as regulating Tlymphocyte function， influencing the behavior of fibroblasts and endothelial cels，catalyzing the tryptophan metabolic pathway，and participating inautoantigen exposure and autoantibody production.This article aims to review the mechanism of IDO in pSS，analyze its potential role in theoccurrence and development of the disease，and look forward to future research directions and therapeutic targets.

[Keywords] Primary Sjogren's syndromeIndoleamine2，3-dioxygenasePathogenesis First-author'saddress：NanjingUniversityofChineseMedicine，Nanjing21oo23，Chin： doi：10.3969/j.issn.1674-4985.2025.31.038

原发性干燥综合征（primary Sjogren's syndrome，pSS）是一种慢性自身免疫性疾病，表现为淋巴细胞浸润到外分泌腺，从而出现眼晴干涩、口干和全身损伤等一系列症状。（剩余16104字）