新辅助治疗联合PD-1抑制剂对局部进展期结直肠癌患者肛肠动力学和肿瘤标志物的影响

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[Abstract]Objective：To analyze the application effect of neoadjuvant therapy combined with programmed death protein-1 （PD-1） inhibitors inpatientswith locally advanced colorectal cancer.Method：Thisarticle was a prospective study.Sixty patients with locally advanced colorectal cancer who were admited to Department of Oncology I，People's Hospitalof Yangjiang from June 2O23 to January 2O25 were selectedas the subjectsand dividedintotwo groupsbytheenvelope method，with30cases ineach group.Thecontrol groupreceivedneoadjuvant chemotherapy with FOLFOX6，and the observation group was treated with PD-1 inhibitor（Sintilimab Injection）onthe basis of thecontrol group.The anorectal dynamics，tumor markers and the incidence of toxic and side effectsbetween the two groups were compared. Result： After treatment， the anorectal dynamics levels were improved in both groups， the maximum systolic blood pressure （MSP），anal resting pressure （ARP）and maximum tolerated volume （MTV） in he observationgroupwerelargerthanthoseinthecontrol group，andtheanorectal inhibitoryreflex threshold（AIRT）and rectal resting pressure （RRP） were lower than those in the control group （ P <0.05）.After treatment， the tumor markers were decreased inboth groups，the levels ofcarbohydrate antigen 19-9 （CA19-9），carcinoembryonic antigen （CEA） in the observation group were lower than those in the control group （ P <0.05）. There was no statistically significant difference inthe incidence of toxic and side efects between the two groups （P>O.O5）.Conclusion： Neoadjuvant therapycombined withPD-1 inhibitors can improve the anorectal dynamics levelsof locally advanced colorectal cancer patients，reduce the tumor markers levels，and does not increase the toxic and side effects.

[KeyWords] Neoadjuvant therapyProgrammed death protein-1 inhibitorsLocally advanced colorectal cancer Tumor markersAnorectal dynamicsToxic and side effects

局部进展期结直肠癌是临床治疗难点，新辅助化疗（NAC）虽然能降低局部复发率，但是病理完全缓解（pCR）率仅有 15%～20% ，患者远期生存获益有限[。（剩余5210字）