多巴胺系统在产后抑郁中的作用机制及研究进展

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Mechanism and Research Progress of Dopamine System in Postpartum Depression/PAN Si，HE Jianbo， CHENHong.//Medical Innovationof China，2025，22（30）： 177-182

[Abstract]Postpartum depression （PPD） is a depressive disorder that occurs in women within 4 to 6 weeks after delivery，with core symptoms including low mood，weakened interest and anhedonia.Itsharmfulness is multidimensional，notonlyseriouslyafectsthephysicalandmental healthofmothers，butalsohasadverseeffects onthebehavioral，emotionalandcognitivedevelopmentof infantsandyoungchildren.Therefore，ithasreceived widespread attention fromsociety.Dopamine （DA），asa keycatecholamine neurotransmiter in thecentral nervous system，participates in regulating emotions，motivation，reward mechanisms，and motor control by regulating multiple neural pathways such as the midbrain limbic pathwayand midbrain cortex pathway.DA receptors have been confirmed as therapeutic targets for various mental disorders，and reduced sensitivityof the DA reward pathway can lead to anhedoniaor lack of motivation，and anhedonia is one of the typical clinical symptoms of depression.Therefore，this article willconduct ananalysis from aspects such as the related factors leading to PPD， the mechanismof the DA system inPPD，andthecurrenttreatment status，aiming to provide references forthe basic research and clinical intervention of DA in the future.

[Keywords] Postpartum depressionDopamine systemTreatment status

First-author's address： Department of Anesthesiology，the Fifth Afiliated Hospital of Xinjiang Medical University， Urumqi83oo11，China

doi：10.3969/j.issn.1674-4985.2025.30.042

产后抑郁（postpartumdepression，PPD）是指产妇在产褥期出现情绪低落、兴趣丧失、思维迟缓、睡眠障碍、食欲不振等，严重时甚至伴有自杀念头的心理疾病，主要在产后4～6周内发生，被认定为重度抑郁症的一种亚型[]。（剩余13334字）