凝血酶散联合艾司奥美拉唑治疗消化性溃疡急性上消化道出血的临床效果

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Clinical Effect of Lyophilizing Thrombin Powder Combined with Esomeprazole in the Treatment of Acute Upper Gastrointestinal Bleeding CausedbyPeptic Ulcer/WUSirong.//Medical Innovationof China， 2025，22（30）： 112-116

[Abstract] Objective：To investigate the effect of Lyophilizing Thrombin Powder combined with Esomeprazole in the treatment of acute upper gastrointestinal bleeding （AUGIB）caused by peptic ulcer.Method： A totalof 87AUGIB patients with peptic ulcer who were treated in Shaowu Municipal Hospital from January 2021 to December 2O23 were selected and divided into the control group （ n =42，given Esomeprazole） and the observation group （ n =45，given Lyophilizing Thrombin Powder combined with Esomeprazole）according to the treatment methods. The hemostasis time，hospital stay，serum indicators of thetwo groups were observed. Result： The hemostasis time of the observation group was earlier than thatofthecontrol group，and hospital staywas shorterthanthatin the control group （ P <0.05）.Two weeks after the treatment，CRP and WBC in both groups decreased，and those in the observation group were lower than those in the control group （ P <0.05）.Two weeksafter the treatment，the levels of hematocrit （HCT），PLT，Hband RBC inboth groups increased，and those in the observation group were higher than those inthe control group （ P <0.05）. Conclusion： The treatment of AUGIB patients with pepticulcer with Lyophilizing Thrombin Powder combined with Esomeprazole hasa significant efect，whichcanshortenthe hemostasis time，accelerate the recovery of the body from bleeding stres，reduce hospitalization period，and promote the recoveryof Hb，RBC，PLT andother indicatorsby reducing blood loss through faster hemostasis.

[KeyWords]Lyophilizing Thrombin PowderEsomeprazolePeptic ulcerAcute upper gastrointestinal bleeding

First-author's address：Department of Gastroenterology，Shaowu Municipal Hospital， Shaowu 54000，China

doi：10.3969/j.issn.1674-4985.2025.30.027

急性上消化道出血（AUGIB）是常见消化系统疾病，主要由消化性溃疡、胃癌或急性黏膜病变导致，临床症状为呕血、黑便、血便等，严重时可导致循环衰竭，危及患者生命安全[。（剩余6195字）