放线菌素D单次给药和5日方案治疗低危侵袭性葡萄胎的临床对比

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Clinical Comparison of Single Dose Administration of Actinomycin Dand5-Day Regimen in the Treatment ofLow-risk InvasiveHydatidiform Mole/HUANG Zhen，ZHULijun，LIU Qing.//Medical Innovation of China，2025，22（30）： 047-050

[Abstract]Objective：To investigate the clinical efficacy of single dose administration of Actinomycin D and 5-day regimen inthe treatment of low-risk invasive hydatidiform mole.Method：Ninetyeight patients with lowrisk invasive hydatidiform moleadmited to Ganzhou Womenand Children's Health Care Hospital from July 2018 to December 2O23 were selected.The patients were divided into two groups according to the different treatment methods of Actinomycin D.Group A （n=51） was treated with a single dose administration of Actinomycin D; group B 0 n =47） was treated with a5-day regimen of ActinomycinD.The total effective rate，serum levels of β -human chorionic gonadotropin （ β -hCG），incidence of adverse reactions were compared，and follow up for6 consecutive monthsafterthe endof thetreatment cycle，the patient's recurrence status was recorded.Result：The totaleffective rate of clinical treatment in group A was 92.16% ，while it was 93.62% in group B， there were no statistically significant differences in the total effective rate，the number of treatment courses required for β -hCG to decrease to normal and the total number of treatment courses （ P- >0.05）.The incidence of adverse reactions in group A was （204 13.73% ，which was lower than 31.91 % in group B （ P <0.05）. During the follow-up period， there were 2 cases of recurrence in group Aand 4 cases of recurrence in group B，there was no statistically significant difference in the recurrence rate between the two groups （ 3.92% vs 8.51% ） χ2 =0.276， P>O.05）. Conclusion： Single dose administration of Actinomycin Dand 5-day regimen can achieve satisfactory therapeutic efects in the treatment of low-risk invasive hydatidiform mole，promoting the recovery of serum β -hCG levels to normal; but compared with the 5-dayregimenof Actinomycin D，single administrationcanreduce the incidence of adverse reactions and is safer.

[Keywords] Low-risk invasive hydatidiform moleActinomycin DChemotherapy Security

First-author'saddress：Department of Gynecology，Ganzhou Womenand Children's Health Care Hospital， Ganzhou 3410oo， China doi：10.3969/j.issn.1674-4985.2025.30.012

侵袭性葡萄胎是一种少见但治愈率较高的与妊娠相关的妇科恶性肿瘤，参照国际妇产科联盟（International Federation of Gynecology and Obstetrics，FIGO）评分系统，可根据患者预后情况分为低危型（FIGO评分 ⩽6 分）和高危型（FIGO评分 >6 分）两类，其中低危侵袭性葡萄胎总体发病率约占滋养细胞肿瘤的 90% 以上，故应引起临床重视[1-2]。（剩余5126字）