肠道菌群-胆汁酸轴与腹泻型肠易激综合征的相关研究进展

Research Progress of IntestinalFlora-Bile AcidAxisand Irritable Bowel Syndrome withDiarrhea/FU Qiannan.//Medical Innovationof China，2025，22（30）：172-177

[Abstract]Irritable bowel syndrome is a common functional gastrointestinal disorder.Its typical clinical manifestations includeabdominal pain，afeling of abdominal distension ordiscomfort，andareusually accompanied bychanges indefecation habitsand stoolconsistency.In recent years，the incidenceof this disease inour country has been increasing yearby year.The occurrence of iritable bowel syndrome with diarrhea （IBS-D）is influenced by multiple factors such as imbalance of intestinal flora，abnormal bileacid metabolismanddysfunctionof the gut-brainaxis.Although theevidence of the interaction between thegutmicrobiotaand bileacid is increasingly abundant in animal models and clinical studies，the specific mechanismsby which the two afectthe occurrence and developmentof IBS-D stillneed to be further explored.This article reviews the intrinsic connection between bile acid，gut microbiotaand IBS-D，aiming to explore innovative therapeutic strategies targeting bileacid metabolism and gut microbiota，providing a new perspective for the treatment of IBS-D.

[Keywords] Irritable bowel syndrome withdiarrhea Gutmicrobiota Bileacid

First-author'saddress：DepartmentofGastroenterology，Afiliated Hospital of Shanxi Universityof lineseMedicine，TaiyuanO3oooo，China doi：10.3969/j.issn.1674-4985.2025.30.041

肠易激综合征（IBS）是一种慢性、功能性胃肠道紊乱疾病，影响肠道的正常功能，其主要临床表现为腹部疼痛、腹部胀满感或不适感，这些症状在排便后往往能够得到一定程度的缓解。（剩余12217字）