响应面法优化柠檬酸一级中和工艺研究

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Research on Optimizing of Citric Acid Primary Neutralization Process by Response Surface Method

QI Sheng， ZHAO Junfeng， SHI Zhen， CAO Shuming，LI Shuo （Laiwu Taihe Bio-Chemical Co.， Ltd.， Jinan 271100， China）

Abstract： In order to improve the yield of tricalcium citrate，the effcts of reaction temperature，reaction time and rotation speed on the yield of tricalcium citrate were analyzed by single factor experiment，and the response surfacetest was used to optimize the citric acid primary neutralization process.The results showed that the optimal process parameters for citric acid primary neutralization were reaction temperature 65∘C ，reaction time 24min and rotation speed 130rmin-1 . Under this process， the yield of tricalcium citrate was 98.67%

Keywords： citric acid; primary neutralization; process optimization; response surface method

柠檬酸（CitricAcid）又称枸橼酸，是在自然界中广泛存在的一类三羧酸类化合物，化学名称为2-羟基丙烷 -1，2，3- 三羟酸，为无色、无臭、半透明的结晶或粉末1]。（剩余4060字）