基于高效液相色谱-串联质谱法检测压片糖果固体饮料、代用茶和果冻中双丙酚丁方法的研究

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Research on the Detection of Dipropofol Butyl in Tablet Candy， Solid Drinks， Substitute Tea and Jelly Based on High Performance Liquid Chromatography-Tandem Mass Spectrometry

WANG Pengxiang （Suzhou Food and Drug Supervision Technology Service Center， Suzhou 234000， China）

Abstract： This paper establishes a method for the detectionof dipropofol butyl in tabletcandies，solid beverages， substitute tea and jelly by high performance liquid chromatography-tandem mass spectrometry. Methanol was used as the extractant toextractthetarget substances inpressed candy，solid beveragesand substitute tea respectively.The substanceswere separated by a C18 chromatographic column （ 50mm×2.1 mm， 1.8μm ），detectedbytandemmass spectrometryand quantified bythe extermal standard method.Theresults show that the concentration of dipropofol butyl has a good linear relationship within the range of 2μg⋅L-1 to 100μg⋅L-1. ，and the correlation coefficient R2 is all above 0.999. The method detection limits were all 0.02mg.kg-1 ，and the quantification limits were all 0.05mg⋅kg-1 The recovery rate of spiked products ranged from 82.2% to 94.3% ， and the relative standard deviations were all less than 10% . This method has good specificity， high sensitivity and wide application range，and can be used for the qualitative and quantitative determination of dipropofol butyl compound in the above-mentioned products.

Keywords： dipropofol butyl; high performance liquid chromatography tandem mass spectrometry; illegal additives

近年来，随着人们生活水平的不断提高，宣称具有减肥功效的食品发展迅猛。（剩余3605字）