食品农药残留的高效液相色谱-质谱联用检测方法优化策略

摘 要：本研究分析了食品农药残留检测中高效液相色谱-质谱联用技术面临的主要挑战，包括检测灵敏度不足、定量准确性受限及复杂基质干扰等问题。通过优化样品前处理方法、改进色谱分离条件、创新质谱检测参数等策略，提出了基质固相分散萃取与同位素内标法相结合的分析方案，有助于提高农药残留检测的灵敏度和准确度。

关键词：液相色谱-质谱联用；农药残留；基质效应

Optimization Strategy of High Performance Liquid Chromatography-Mass Spectrometry Method for Detection of Pesticide Residues in Food

HUANG Fang， YANG Chaobo， WEI Xuefei， LI Changda

（Pan’an County Food and Drug Inspection Center， Jinhua 322300， China）

Abstract： This study analyses the main challenges faced by high performance liquid chromatography-mass spectrometry in the detection of pesticide residues in food， including insufficient sensitivity， limited quantitative accuracy and complex matrix interference. By optimizing sample pretreatment method， improving chromatographic separation conditions and innovating mass spectrometry detection parameters， an analytical scheme combining matrix solid phase dispersion extraction and isotope internal standard method was proposed， which was helpful to improve the sensitivity and accuracy of agricultural residue detection.

Keywords： liquid chromatography-mass spectrometry; pesticide residues; matrix effect

近年来，随着农药在农业生产中的广泛使用，食品中农药残留问题日益突出，已成为影响食品安全的重要因素之一。（剩余4315字）