两种虫草菌发酵荆芥的代谢组分析

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关键词：虫草菌；真菌发酵；荆芥（NepetacatariaL.）；代谢组；黄芩苷

中图分类号：Q946 文献标识码：A

文章编号：0439-8114（2025）08-0140-07

DOI：10.14088/j.cnki.issn0439-8114.2025.08.021 开放科学（资源服务）标识码（OSID）：1

Analysis of the metabolome of Nepeta cataria L. fermented with two types of Cordycipitaceae strains

XU Yu-sheng，ZHANG Chun-hua，LI Zhen-yu，PENG Chun-ying，SHAN Zhi-guo （SchlfeadCfYuanInteatioalJntLabatoryigitalCoseatodGsmotidAafaLo TeaResources，Pu'erUniversity，Pu'er665OOO，Yunnan，China）

Abstract：InordertoinvestigatetheefectsofCordycipitaceae40and44fermentationonthemetabolicproductsof Nepetaataria， theexperiment was dividedintothree groups（JK group，J40 group，andJ44group），andthe metabolitesof Nepetacatariaandthe main metabolicpathways beforeandafterfermentationwereanalyzed using metabolomicsmethods.Theresults indicated that，comparedtothe JKgroup，theupregulationofsubstancessuchasphenolicacids，aminoacidsandtheirderivatives，andflavonoids were more pronouncedafterfermentationwithCordycipitaceaestrains40and4in Nepetacataria.Theclusterheatmaprevealedthatthe J40grouphad65upregulateddiferentialvariables，withaminoacidsandtheirderivativesaccountingforthelargestproportion 0 24.15% ）；there were 388 downregulated diferential variables，with phenolic acids constituting the majority （ 21.39% ）. In group J44，178 differential variables were upregulated，with phenolic acids accounting for the highest proportion （ 16.85% ）；258 differential variables were downregulated，with phenolic acids also accounting for the highest proportion （ 23.64% ）.Among these，the product with the most significant metabolic difference was baicalin.

Key words：Cordycipitaceae；fungal fermentation； Nepeta cataria L.；metabolomics；baicalin

荆芥（NepetacatariaL.）为唇形科荆芥属多年生草本植物，在中国最早记载于《吴普本草》，是中国重要的药食兼用中药材[12]。（剩余7361字）