红斑丹毒丝菌蛋白间相互作用网络的构建与分析

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关键词：红斑丹毒丝菌（Erysipelothrixrhusiopathiae）；蛋白间相互作用；互作网络

中图分类号： R378.99+5;Q51 文献标识码：A

文章编号：0439-8114（2025）07-0137-05

DOI：10.14088/j.cnki.issn0439-8114.2025.07.024 开放科学（资源服务）标识码（OSID）：口

The construction and analysis of the protein-protein interaction network of Erysipelothrixrhusiopathiae

WUXue-jun1，DONG Qi²，ZHOU Cai-qin1，ZHANGXiao-wei1，LIUWei³ （1.ZhejangCeefoaleasetrodretioHangou，ina;uaagCitanfegCotyalsd VeterinaryDevelontCnteruagag48OHubei，hia;3KeyboratorofrevetodtrolAgentsnalcteriois （MinityofAltueanduralfis）/ubeiProvalKeyboratoyfalatogccobIstitutefAialHusbadryd Veterinary，HubeiAcademy ofAgricultural Sciences，Wuhan 43OO64，China）

Abstract：Analysisofteinteractionbetweenpathogenicproteinsasanimportantwaytounderstandtheirlifeactivites，eveathe signaltransductionmechanism，andpredictpotentialdrugtargets.Theaimofthisstudywastoconstructacomprehensiveinteraction networkbetweentheencodedproteinsofErysipelothrixrhusiopathiaebyusingtheDIPproteininteractiondatabaseandthehoolgous proteinmappingmethod.Theconstructedinteractionnetworkcontains113pairsofnon-redundantinteractions involving30pro teins.Ouranalsisunraveled40proteinswithhighestinteractionsinthenetwork，andmostofthemwererelatedtotranslationtranscription，molecularchaperone，andother functions.Furtheranalysis showed that chaperone proteins DnaK，DnaJ，GroELand DEAD/DAHhelicases hadhighinteractionfrequenciesandcouldinteract withmultiplefunctionalproteinssuchasribosomalproteins，metabolicallrelatedproteins，chaperoneproteins，andcelldivisionproteins.Theresultssugestedthatif thefunctinsof DnaK，DnaJ，GroEL，EAD/DEAHelicasesereibited，tenoalifectivitsofErysipelothixrusiopathaeouldbeeat ly affected.

KeyWords：Erysipelothrixrhusiopathiae；protein interaction；interaction network

猪丹毒是由红斑丹毒丝菌（Erysipelothrixrhusio-pathiae）引起的一种重要的人畜共患传染病。（剩余6400字）