如皋市2014—2024年手足口病流行特征及影响因素的研究

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Study on Epidemiological Characteristicsand Influencing Factors of Hand Foot and Mouth Disease in Rugao City from 2014 to 2024/GAO Liyong， CAI Meiling.//Medical Innovation of China，2025，22（29）： 166-170

[Abstract]Objective：To explore the epidemiological characteristics and influencing factors of hand foot and mouth disease （HFMD）in Rugao Cityfrom 2014 to 2024，to provide a scientific basis for formulating precise regional prevention and control strategies.Method： A totalof 112，832 children with complete surveilance data from Rugao Center forDisease Control and Prevention from January 2014 to December 2O24 were selected as the study subjects. Among them，12，832 children with HFMD were assigned to the observation group，while the remaining 100.000 healthy children were selected as thecontrol group.Theepidemiological characteristics of HFMD inchildren in Rugao City was investigated;therisk factors for theoccurrenceof HFMD inchildren inRugao City wereanalyzed. Result：HFMD exhibited significant seasonal clustering，with peak incidence in summer （38.86 % ） and winter （27.20 % ）; more han 85%of cases were distributed in childrenunder the age of5，with theO-2age group having the highest number of cases，accounting for 46.65 % （5，986 cases）; the second group was the age group >2-5 years old， accounting for 40.08 % （5，143 cases）. The incidence rate of children over 5 years old decreased significantly with age.Multivariate analysis of HFMD in Rugao from2O14 to 2O24 revealed that being youngerthan 5 yearsOR=2.06， 95%CI （1.94，2.18）， being male [OR=1.52， 95%CI （1.45，1.60）]， having a history of HFMD [OR=27.00， 95%CI （25.17，28.97）]，having stayed indensely populatedareas within the past week [OR=4.46，95%CI （4.23，4.70）]，and residing in rural areas [OR=2.25，95%CI （2.14，2.37）] were independent risk factors for HFMD incidence （ P <0.05）. Conclusion： HFMD prevention in Rugao Cityshould focus on childrenunder5 years old， males，rural populations and those with contact history.Strengthen vaccination，health education，and management of crowded areas，while paying attention to the trend of non-EV71 viral variants.

[Keywords] Hand foot and mouth disease Epidemiological characteristicsRisk factors logistic regression Rugao City

First-author'saddress： Office ofRugao Center for Disease Control and Prevention，Rugao 226500， China

doi：10.3969/j.issn.1674-4985.2025.29.039

手足口病（hand footand mouthdisease，HFMD）是由肠道病毒引起的急性传染病，以发热、口腔黏膜溃疡及四肢末端疱疹为主要临床特征，重症病例可并发脑炎、肺水肿等严重并发症[。（剩余5256字）