替罗非班联合替格瑞洛治疗急性心肌梗死 PCI术后患者的效果观察

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Observationon theEffectof TirofibanCombined with TicagrelorintheTreatmentofPatientswith Acute Myocardial Infarction Undergoing PCI/XIA Rihui， XIONG Dandong，WU Gaoxiang.//Medical Innovation ofChina，2025，22（29）：025-029

[Abstract]Objective：To investigate the effects of Tirofibancombined with Ticagrelor oncardiac function and majoradversecardiovascular events inpatients with acute myocardial infarction （AMI） undergoing percutaneous coronary intervention （PCI）.Method：A retrospective analysis was conducted on 84 AMI patients who underwent PCI in Fengcheng People's Hospital from January 2O21 to January 2O24.They were divided into two groups according todiffrent treatment methods.Thecontrol group（n=42）was treated with Ticagrelor，whiletheobservation group （ n =42）wastreated with Tirofibanon thisbasis.The clinical eficacy，coronaryblood flow indicators，cardiac function，serum inflammatory factorsand the incidence of majoradverse cardiovascular events were compared between the two groups.Result： The total effective rate of treatment in the observation group was 92.86 % ，which was higher than 76.19% in the control group （ P <0.05）. After treatment， the diastolic peak velocity （DPV）， systolic peak velocity （SPV），coronaryflow velocityreserve （CFVR），and leftventricular ejection fraction（LVEF）of the leftanterior branch inthe observation group were allhigher than those in thecontrol group;the left ventricular end-diastolic diameter （LVEDD）， IL-6， TNF- α ，and hs-CRP were all lower than those in the control group （ P <0.05）. The incidence of major adverse cardiovascular events in the observation group （4.76% ）was lower than that in the control group （19.05 % N P <0.05）. Conclusion： The treatment of AMI patients undergoing PCI with Tirofiban combined with Ticagrelor hasachievedremarkable results.The coronary blood flow and cardiac function of the patients have been effectivelyimproved，theinflammatoryresponse hasbeen effectivelyalleviated，andthe incidence of majoradverse cardiovascular eventsisrelatively low.

[KeyWords] Acute myocardial infarction Percutaneous coronary intervention Tirofiban Ticagrelor Heart function Major adverse cardiovascular events

急性心肌梗死（AMI）是一种急性病症，由冠状动脉急性阻塞引起，会导致心肌缺氧、缺血，损伤患者心功能，危及患者生命安全。（剩余6131字）