急性致残性非大血管脑梗死患者阿替普酶 动脉溶栓的早期疗效观察

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EarlyEfficacy Observationof AlteplaseArterial Thrombolysis inPatients with Acute DisablingNonlarge Vessel Cerebral Infarction/CHEN Houqin， YANG Jinping，SHI Dongyan， ZHANG Jinfeng， XUDan， CAO Yanqiu，YUANLei， XIAO Guodong.//Medical Innovationof China，2025，22（29）： 038-042

[Abstract]Objective： To observe the early eficacyand safety of Alteplase （rt-PA）arterial thrombolysis in the treatment of acute disabling non-large vessel cerebral infarction patients.Method： Aretrospective study was conducted on 8O patients with acute disabling non-large vessl cerebral infarction admitted to Taicang Affiliated Hospital of Nanjing University of Chinese Medicine from January 2O22 to March 2O24.They were divided into two groups according to the treatment methods.The arterial thrombolysis group （4O cases）underwent digital subtraction angiography （DSA） examination and received rt-PAarterial thrombolysis treatment，whilethe control group （40 cases）received standard dose rt-PA intravenous thrombolysis.The degree of neurological damage （NIHSS score）， inflammatory response indicators （hs-CRP， IL-6， TNF- α ），daily living ability evaluation （Barthel index score） before and after treatment，and incidence of adverse events between two groups were compared. Result： The NIHSS scores of the arterialthrombolysis group were lower than those of the control group at each observation time point after treatment （ P <0.01），the levels of hs-CRP，IL-6，and TNF- α in the arterial thrombolysis group were lower than thosein the control group （ P <0.01）.Fourteendaysafter treatment， thedailybasic self-carerate in the arterial thrombolysis group was higher than that in the control group （ P <0.05）. There were no statistically significant differences in the intracranial hemorrhage rate and other systemic hemorrhage rate betweenthe two groups of patients （ P> O.05）.Conclusion： rt-PA arterial thrombolysis has good early eficacy and safety in patients with acute disabling non-large vessel cerebral infarction.

[KeyWords] Arterial thrombolysisAcute cerebral infarction Responsible blood vesselsAlteplase

First-author's address： Department of Brain Diseases， Taicang Affiliated Hospital of Nanjing UniversityofChineseMedicine，Taicang2154oo，China doi： 10.3969/j.issn.1674-4985.2025.29.009

急性致残性非大血管脑梗死是脑卒中的一种常见类型，其具有高致残率、致死率及高复发率的特点[。（剩余6928字）