丙泊酚复合氯化琥珀胆碱对行改良电休克治疗的难治性精神分裂症患者的影响

打开文本图片集

The Influence of Propofol Combined with Succinylcholine Chloride on Patients with Refractory Schizophrenia Undergoing Modified Electro-convulsive Therapy/LU Yuan，SU Jianning，XIAO Xiumei， TUXiaofang.//Medical Innovation of China，2025，22（24）： 168-171

[Abstract] Objective： To explore the influence of Propofol combined with Succinylcholine Chloride on electroencephalogram，cognitive function and muscle pain status in patients with refractory schizophrenia undergoing modified electro-convulsive therapy （MECT）.Method：A total of 7O patients with refractory schizophrenia who underwent MECT in the Third People's Hospital of Ganzhou from May 2023 to May 2O24 were selected and divided into group A（Etomidate combined with Succinylcholine Chloride，n=31）and group B（Propofolcombined with Succinylcholine Chloride， n =39）according to different anesthesia methods.The bispectral index （BIS），VAS score，MATRICS consensus cognitive battery （MCCB） score and the incidence of adverse reactions between the two groups at diferent time points were compared.Result： Immediately before MECT，the BIS of both groups were lowerthan those before anesthesia，buttheBISof group Bwas higher than thatof group A，the diferences were statistically significant （ P <0.05）.At 30 min，2 hand 12h after the first MECT，the VAS scores of group B were all lower than those of group A， the differences were statistically significant （ P <0.05）.After1 course of treatment， the MCCB score of group A was significantly lower than that before MECTtreatment andthat of group B，the diferences were statistically significant （ P <0.05）.There was no statistically significant difference in the incidence of adverse reactions between the two groups （P>0.O5）. Conclusion： For patients with refractory schizophrenia undergoing MECT，anesthesia with Propofol combined with Succinylcholine Chloride before treatmentcan reduce the impacton cognitive function and electroencephalogram，alleviate the muscle pain of patients，and has high safety.

[Keywords]Propofol Succinylcholine ChlorideModified electro-convulsive therapyRefractory schizophreniaElectroencephalogram

First-author'saddres： MECTRoom，the Third People's Hospital of Ganzhou，Ganzhou 341ooo， China doi：10.3969/j.issn.1674-4985.2025.24.039

精神分裂症在临床上具有较高的发病率，是一种慢性精神疾病，临床上主要表现为精神活动不协调及个人行为、情感、感知的异常。（剩余5788字）