右美托咪定预处理对妇科手术患者全身麻醉诱导期血流动力学的影响

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Influence of Dexmedetomidine Pretreatment on Hemodynamics during the Induction Period of General Anesthesia inPatients Undergoing Gynecological Surgery/ZHANGMeixiu，WANGJinghua，QIU Lin.//Medical Innovation of China，2025，22（24）：150-154

[Abstract] Objective： To explore the effect of Dexmedetomidine pretreatment on hemodynamics during the induction period of general anesthesia in patients undergoing gynecological surgery. Method： A total of 100 gynecological surgery patients who underwent general anesthesia inFuzhou Maternal and Child Health Hospital from January 2O23 to August 2O24 were selected and divided into the observation group （ n= 53）and the control group （ n =47）by the random number table method.Before anesthesia induction，Dexmedetomidine at a dose of was continuously pumped intravenously into the observation group，while the control group was given the same dose of 0.9% Sodium Chloride Injection. The anesthesia effects，hemodynamic indicators （mean arterial pressre，heart rate，and electroencephalogram dual-frequency index） before anesthesia induction （Ti）， before intubation （T2），immediately after intubation （T3），and1 minute（ Γ4） ，3minutes （T 5） ，and5 minutes （T6）after intubation were compared betweenthe two groups.Result： There were no significant diferences inanesthesia onsetor recovery times between the two groups （ P >0.05）.The mean arterial pressure in the observation group at I3 and Γ4 were significantly lower than those in the control group （ P <0.05）. Heart rate at Γ3 and T4 were also significantly lower in the observation group compared to the control group （ P <0.05）. The bispectral index values in the observation group at T1， T4 and T5 were significantly reduced compared to those in the control group （ P <0.05）.Conclusion：Dexmedetomidine pretreatment efectively stabilizes hemodynamic indicators during anesthesia induction for gynecological surgery， significantly reducing fluctuations in mean arterial pressure and heart rate following intubation and maintaining a stable bispectral index.

[Keywords] DexmedetomidineGynecological surgery General anesthesia Anesthetic effects Hemodynamics

First-author'saddress： Anesthesiology Department，Fuzhou Maternal and Child Health Hospital Izhou 344000，China

doi：10.3969/j.issn.1674-4985.2025.24.035

全身麻醉是妇科手术中常见的麻醉方式，但在麻醉诱导和气管插管过程中，患者容易出现血流动力学波动，如血压升高、心率加快及心律失常等应激反应[1-3]。（剩余6602字）