血清BNP、cTnI水平与冠心病心力衰竭患者心肌重构的关系

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Relationshipbetween SerumBNPandcTnILevelsandMyocardialRemodelinginPatientswith Coronary Heart Disease and HeartFailure/HUJie，GUWen.//Medical Innovationof China，2025，22（24）： 121-125

[Abstract]Objective： To analyze the correlation between the changes in serum brain natriuretic peptide （BNP）and cardiac troponin I（cTnl） levels and myocardial remodeling in patients with coronary heart diseaseand heartfailure.Method： Aretrospectiveanalysis was conducted on15O patients with coronary heartdisease and heart failureadmited to Xinyu People's Hospital from March 2O22 to October 2O24.According to the left ventricular mass index （LVMI）and leftatrial volume index （LAVI） calculatedbyechocardiography，thepatients were divided into the myocardial remodeling group （45 cases） and the non-myocardial remodeling group （1o5 cases）. Univariate analysis and multivariate logistic regression analysis were used to identifythe independent influencing factors;and ROC curve was drawn to evaluate the predictive value of BNP and cTnI on myocardial remodeling in patients with coronary heart disease and heart failure.Result：The univariate analysis results showed that the BNP，cTnI in the myocardialremodeling group were higher than those inthe non-myocardial remodeling group，the differences were statistically significant（ P <0.05）. The results of multivariate logistic regresson analysis showed thatBNP，cTnI were all risk factorsaffcting myocardial remodeling in patients with coronary heart disease and heart failure （ P <0.05）.The AUC of BNP and cTnI for predicting myocardial remodeling were O.743 [95%CI （0.654， 0.832）] （ P <0.001） and 0.637 [95%CI （0.537， 0.737）] （ P =0.008），respectively.Conclusion：BNP and cTnI are closely related to myocardial remodeling in patients with coronaryheart disease and heart failure and can be used asimportant biomarkers for evaluating myocardial remodeling.

[Keywords] Coronary heart diseaseHeart failureMyocardial remodeling

First-author'saddress：DepartmentofCritical Care Medicine，XinyuPeople'sHospital，Xinyu338000， China

心力衰竭是一种心脏泵血功能受损的临床综合征，无法满足身体正常代谢需求[。（剩余5522字）