高频重复经颅磁刺激联合舍曲林治疗青少年抑郁症的效果

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Effect of High-frequency Repetitive Transcranial Magnetic Stimulation Combined with Sertraline in the Treatmentof AdolescentDepression/LIDexin.//Medical Innovationof China，2025，22（24）：164-167

[Abstract]Objective： To explore the efect of high-frequency repetitive transcranial magnetic stimulation combined with Sertraline in the treatment of adolescent depression.Method：A total of1O7 adolescent depression patients admited to Ji'an Third People's Hospital from October 2021to October 2023 were selected as the research objects，and were divided into the experimental group （57 cases）and the control group （5O cases）according to the odd and even numbers of medical records，in which the experimental group was treated with high-frequency repetitive transcranial magnetic stimulation combined with Sertraline，whilethe control group was treated with single Sertraline，and the negative emotions of patients and the improvement effects of symptoms and indicators under diferent treatment methods were recorded respectively.Result：After 4，6and 8 weeks of treatment，the HAMD-24 scores of patients in the experimental group were lower than those in the control group，the differences were statistically significant （ P <0.05）.After 4，6 and 8 weeks of treatment， the SDS scores of patients in the experimental group were lower than those inthe control group，the diffrences were statisticallysignificant （ P <0.05）. Compared with the control group，the atention impulse，motor impulse and unplanned impulse after treatment in he experimental group were significantly lower，the differences were statistically significant （ P <0.05）. Moreover， the improvementefectof adrenaline（NE），dopamine （DA），5-hydroxytryptamine （5-HT）at8 weeksaftertreatment in the experimental group were beter than those in the control group，the differences were statistically significant （ P <0.05）. Conclusion： High-frequency repetitive transcranial magnetic stimulation combined with Sertraline hasasignificant clinical improvement efectonadolescentdepression，and itsnegative emotions have been better alleviated，depression and neurotransmitters have been improved.

随着社会的发展，人们的生活方式和节奏也在不断地发生变化，受环境、家庭、学习等因素的影响，青少年抑郁症的发病率呈现出逐年上升趋势，引起了广泛关注。（剩余5303字）