葫芦素B的药理作用及其机制研究进展

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关键词：葫芦素B（CucurbitacinB，CucB）；药理作用；作用机制中图分类号：R96 文献标识码：A文章编号：0439-8114（2025）12-0137-09DOI：10.14088/j.cnki.issn0439-8114.2025.12.023开放科学（资源服务）标识码（OSID）：

Research progress on the pharmacological effects and mechanisms of cucurbitacin B

PANXiao-fang1，GAOMei-fei²，CHENRui²³，HUOLi-ni²，ZHUHai-bin （1.Xiangsiullg，GuangiMnuUniversitangO2，hia;.ColgeofaacyuangiUiversityofedii Nanning5O2;GagiVatioaUsiture2;siutese PharmaceuticalScience，Nanning53oo22，China）

Abstract：TheresearchprogressonthebiologicalactivitiesandmechansmsofactionofcucurbitacinB（CucB）wasreviewed.Studies showedthatCucB posesed significantantitumor efects.It was found toregulatemultiplesignaling pathways，including JAK2/ STAT3，PI3K/A，APK/RK，ndopois，hrebyectivelybiingteroliferation，igaiondivasionfriou tumorcells（suchastosefromliver，lung，breast，ndgastrontestialcancers）andinducingcellcyclerest，apoptosis，andutophagy.Intersofanti-flammatoryeects，CucBcouldinibittheactivatiooftheNRP3inflammasomeanddoweglatekey pathwayslikeNF-eB，thusallvitingtissedamageinultipleinflammatorymodels.Furthermore，ucBemonstratedhpatorotetiveactityandassowntoameliorateliverfrosisthoughmodulatingoxidativestress，uppressinginflmmatoryesponss，and regulatingaxessuchasSIRT/IGFBPrP1/TGF-a1.Itspotentialinallviatingpsoriasiswasalsosupportedbyresearch，withmechanismsinvolvingtheinhibitionofpathwayssuchascGAS-STNGandJAK-STAT.OtherefectsofCucB，includingitsroleigulatingautophagyuppressinglukeiaandteosrcoaroteingsuladothelundbiigottialurotoiiyee also summarized.

KeyWords：cucurbitacinB（CucB）；pharmacological activities；mechanism of action

葫芦素B（CucurbitacinB，CucB）是来源于葫芦科植物的氧化四环三萜类物质，结构见图1。（剩余15377字）