基于铁代谢的中药活性成分防治蒽环类药物心脏毒性的机制

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[Abstract]Anthracyclines are the first-line treatment for cancer chemotherapyand playa significant role in significantly improving patients'survival rates.However，the isse of cardiotoxicitycaused by these drugs cannot be ignored.Currently，the mechanismofcardiotoxicityof these drugs isnotfullyunderstood.Inmanyrelated studies， abnormal ironmetabolism is regarded as oneof the important mechanisms.Specificaly，anthracyclinescanform chelation reactions with iron ions，thereby generating oxygen free radicals.These oxygen freeradicals can cause a series of damage effcts，such as inducing lipid peroxidation reactions in the myocardial cell membrane and damaging the mitochondrial DNAof the myocardium，ultimatelyleading tothedeath of myocardial cels.This article aims to review the research progress on the prevention and treatment of cardiotoxicity caused by anthracyclines through regulating the iron metabolism pathway by the active ingredients of traditional Chinese medicine.

[KeyWords] Anthracyclines-induced cardiotoxicityIron metabolismActive ingredients of traditional Chinese medicine

First-author'saddress：Department of Rehabilitation Medicine，Gansu Provincial Hospital of TraditionalChineseMedicine，Lanzhou73oo5o，China doi：10.3969/j.issn.1674-4985.2026.07.035

蒽环类药物（ANT）在癌症治疗中效果显著，然而，其临床应用受到剂量依赖性心脏毒性的严格限制。（剩余7696字）