HER2在晚期转移性结直肠癌中的研究进展

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[关键词」转移性结直肠癌;人表皮生长因子受体 2;高通量核苷酸序列分析;循环肿瘤 DNA;分子靶向治疗[中图分类号］R735.3 [文献标志码］A [文章编号] 2096-5532（2025）03-0465-05doi：10.11712/jms.2096-5532.2025.61.072 [开放科学（资源服务）标识码（OSID）][网络出版]https：//link.cnki.net/urlid/37.1517.R.20250627.1107.004； 2025-06-2716：38：44

Research advances inHER2 in advanced metastaticcolorectal cancerZHAO Peipei，WANG Zhihai，LI Mingyue，SUN Shuolan，JUFang（Schoolof Clinical Medicine，Shandong Second Medical University，Weifang 261ooo，China）

[Abstract] Colorectal cancer is a common malignant tumor of the digestive tract，and about 20% of patients have distant me tastases at initial diagnosis，while 5% of metastatic colorectal cancer （mCRC） cases are of the human epidermal growth factor receptor2（HER2）varianttype.HER2-positive mCRC patients who have failed standard treatmentcansignificantly benefit from HER2-targetedtherapy.Thisarticlereviewstherecentresearchadvancesindetectionmethods，diagnosticcriteriaprognosticsig nificance，andtargetedtherapiesforHER2inmCRC，inorder toprovideareferenceforHER2-relateddiagnosisandtreatmentin mCRC patients in clinical practice.

[Key words]metastatic colorectal cancer;humanepidermal growth factorreceptor 2；high-throughput nucleotide sequencing；circulating tumor DNA；molecular targeted therapy

结直肠癌（CRC）的发病率和死亡率分别位列全球常见恶性肿瘤的第3位和第2位，在我国的发病率和死亡率也持续攀升。（剩余14730字）