聚多巴胺纳米颗粒对6-OHDA诱导的帕金森病小鼠运动行为影响

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[关键词] 帕金森病；多功能纳米颗粒；羟多巴胺；运动活动；小鼠[中图分类号]R338.2；R742.5 [文献标志码］A [文章编号] 2096-5532（2025）03-0341-04doi：10.11712/jms.2096-5532.2025.61.085 [开放科学（资源服务）标识码（OSID）][网络出版]https：//link.cnki.net/urlid/37.1517.R.20250716.1047.008; 2025-07-1615：09：52

Effectof polydopaminenanoparticlesonthemotorbehaviorof micewithParkinson’sdiseaseinducedby6-hydroxydopamine ZHANG Jing，SHI Yaying，ZHAO Di，XIE Junxia，SHI Limin （DepartmentofPhysiologyand Pathophysiology，School ofBasic Medicine，Qingdao University，Qingdao 266071，China）

[Abstract]ObjectiveToinvestigate theeffectof polydopamine nanoparticles（PDANPs）onthe motor behaviorof mice with Parkinson’s disease（PD）inducedby6-hydroxydopamine（6-OHDA）.MethodsMaleC57BL/6 mice，aged8 weks，were selectedas experimentalanimalsand weredivided intoControl group，PDANPstreatmentgroup（PDA group），modelgroup（6- OHDA group），and combined treatment group（6-OHDA + PDA group）. The stereotactic injection technique was used to inject 2 μL of working solution intothecorpus striatum.Aftertwo weeks，the open field test，therotarod test，andthe pole test were usedto assessthe motor behaviorof mice.ResultsCompared with theControl group，the6-OHDA group hada significant reduction in total distance in the open field test （F=14.180，q=8.855，P<0.001） ，significant increases in the time to turn around and the time from the top to the bottom of the pole in the pole test （F=22.090，6.912，q=10.960，5.865，P<0.01） ，and a significant reduction in the latency on the rotarod in the rotarod test （F=8.635，q=6.628，P<0.001） .Compared with the 6-OHDA group，the 6-OHDA+PDA group had a significant increase in total distance in the open field test （q=5.821，P<0.05） ，significant reductions in the time to turn around and the time from the top to the bottom of the pole in the pole test （q=7.232，4.192，P< 0.05），and a significant increase in the latency on the rotarod in the rotarod test ⟨q=4.764，P<0.05） .ConclusionPDA NPs treatmentcan aleviate 6-OHDA-induced motor behavioral damage in mice and improve spontaneous movementand coordination disorders in mice.

[Key words]Parkinson disease；multifunctional nanoparticles；oxidopamine；motor activity；mice

帕金森病（PD）是第二常见的神经退行性疾病，其主要的病理改变是中脑黑质多巴胺（DA）能神经元渐进性的变性死亡[2]。（剩余8620字）