6-OHDA诱导帕金森病模型小鼠的疼痛及抑郁样行为

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[关键词」帕金森病；羟基多巴胺类；纹状体；疼痛；抑郁；小鼠[中图分类号] R338.1 [文献标志码] Adoi：10.11712/jms.2096-5532.2025.61.080[文章编号] 2096-5532（2025）03-0368-03[开放科学（资源服务）标识码（OSID）]

[网络出版] https：//link.cnki.net/urlid/37.1517.R.20250716.1001.002; 2025-07-1615：10：23

Painand depression-likebehaviorsinamouse modelof Parkinson'sdisease induced by6-hydroxydopamineSHIYaying，ZHANG Jing，XIEJunxia，SHI Limin （Department of Physiology and Pathophysiology， School of Basic Medicine，Qingdao University，Qingdao 266071，China）

[Abstract]ObjectiveToinvestigate whethertherearepainhypersensitivityanddepresion-likebehaviorsinamousemodel ofParkinson’sdisease（PD）establishedbyinducingunilaterallesionof thecorpusstriatumusing6-hydroxydopamine（6-OHDA）. MethodsAtotalof17C57BL/6mice，aged7weeks，wererandomlydivided intocontrolgroup（injected with normal saline）and model group （injected with 6-OHDA），and the method of stereotactic injection was used to inject 2μL of normal saline or 2.5g/L 6-OHDAintotheleftcorpus striatum.After2 weeks，theVonFreytest，thetail suspensiontest，andtheforced swimming test were performed to measure the 50% hind paw withdrawal threshold and the percentage of immobility time.ResultsThe von Frey test showed that compared with the control group，the model group had a significant reduction in 50% hind paw withdrawal threshold and showed pain hypersensitivity ζt=6.854 ， P<0.001 ）.Thetail suspension test and the forced swimming test showed thatcompared with thecontrol group，the model group hada significant increase in the percentageofimmobility time（ t=3.828 ， 2.958， P<0.05 ）.ConclusionPain hypersensitivityand depression-like behaviors are observed in a mouse model of PD established by inducing unilateral lesion of the corpus striatum using 6-OHDA.

[Key words]Parkinson disease；hydroxydopamines；corpus striatum；pain；depression；mice

帕金森病（PD）是一种常见的中枢神经系统退行性疾病，其病理学特征为黑质致密带多巴胺能神经元的选择性缺失[1-3]。（剩余6429字）