光甘草定纳米粒子的制备及其对帕金森病小鼠运动功能影响

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[关键词]帕金森病;1-甲基-4-苯基-1，2，3，6-四氢吡啶;光甘草定;纳米颗粒给药系统;运动活动;小鼠[中图分类号] R338.2；R742.5 [文献标志码]A [文章编号] 2096-5532（2025）03-0317-05doi：10.11712/jms.2096-5532.2025.61.075 [开放科学（资源服务）标识码（OSID）][网络出版]https：//link.cnki.net/urlid/37.1517.R.20250709.1559.002; 2025-07-10 11：57：52

[Abstract]ObjectiveTo prepare glabridin nanoparticle，andto investigateits efectonmotorfunctionin mice with Parkinson'sdisease（PD）induced by1-methyl-4-phenyl-1，2，3，6-tetrahydropyridine（MPTP）．MethodsGlabridinand polydopamine（PDA）wereused tosynthesize glabridin nanoparticles（Glab-PDANPs）through self-assmbly，andthen Glab-PDA NPs werecharacterized.A total of 24 C57BL/6 mice，aged 8 wees，were randomlydivided into MPTPgroup，Glab-PDA NPs treatment group，and control group，with 8 miceineach group.The micein the MPTP group and the Glab-PDA NPstreatment group were given intraperitoneal njectionof MPTPtoestablishamodelofsubacutePD.The miceinthe Glab-PDANPs treatment group were given injectionofGlab-PDANPsthroughthecaudalveinsinceday3before modelingtilltheendof modeling，whiletose in thecontrolgroup wereinjected withanequalvolumeof normal saline.Therotarodtestandthegaittest wereusedtoasessthe motorabityof mice.ResultsThe homogeneous round Glab-PDANPs were prepared succesfull，witha drug encapsulation efficiency of 40% and a drug loading content of 8.7% . The rotarod test showed that the MPTP group had a significantly worse motor coordination ability than the control group （F=5.97，q=2.778，P<0.05） ，while the Glab-PDA NPs treatment group showed significant recovery of motor function . The gait test showed that the MPTP group had significant reductions in the motor ability of the limbs （F=3.03-52.82，q=2.374-9.521，P<0.05） ，while the Glab-PDA NPs treatment group had significant improvements in the indicators of the limbs ⋅q=2.826-8.198，P<0.05） .ConclusionGlab-PDA NPs can improve motor function and restore motor ability in PD mice.

[Key words]Parkinsondisease；-methyl-4-phenyl-1，2，3，6-tetrahydropyridine；glabridin；nanoparticledrugdeliverysys temmotorabilities；motor activity；mice

帕金森病（PD）是继阿尔茨海默病后第二大常见的神经退行性疾病，病人多为中老年群体[1-2]。（剩余11328字）