不同低氧耐力飞行人员训练前后尿中皮质醇和睾酮及其代谢产物比较

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[中图分类号]R852 [文献标志码］A [文章编号] 2096-5532（2025）03-0391-04 doi：10.11712/jms.2096-5532.2025.61.094 [开放科学（资源服务）标识码（OSID）]i [网络出版] https：//link.cnki.net/urlid/37.1517.R.20250731.1609.004; 2025-08-0113：29：05

Comparisonofurinarycortisolandtestosteroneandteirmetabolitesamongaviationpersonnelwithdifferenthypoxicendurancelevels before and after training ZHENG Hongxia ， PAN Xiangrong， WANG Peng， TIAN Jianquan， WANG Zheng，LIN Shuang （Qingdao Special Servicemen Recuperation Center of PLA Navy，Qingdao 266O71，China）

[Abstract]ObjectiveTocomparetheurinarycontentofcortisol，testosterone，andtheir metabolitesamongflight person nelwithdiferenthypoxiatolerancelevelsbeforeandaftertraining，andtofindconvenientdetectionindicatorsforimmediatehy poxiatoleranceaessmentforflightpersonel.MethodsMaleflightpersonnelwhounderwenthypoxiatolerance trainingatour center were selected.Using the KK-1type anti-Gandanti-hypoxia detection device developed byamedicalresearchinstitute，30 participants eachwereselectedintothreegroupsaccordingtothehypoxiatoleranceresults：qualifiedgroup，goodgroup，and excellentgroup.Bygaschromatography-masspectrometry，thethree groupswere measuredforthelevelsofcortisol，testosteroneand their metabolites，including epitestosterone（ET），etiocholanolone（Etio），androsterone（ An） ， 5α -androstane 3α 17β⋅ diol（5α）， 5β⋅ androstane 3α，17β -diol （5β） ，11-hydroxytestosterone（11-OHT），11-hydroxyandrostenedione（11-OHA4），17-hydroxycorticosteroids（17-OH），and17-ketosteroids（17-O）beforeandaftertraining.ResultsAcrossthethre groups，thelevelsof theindicators were all significantly increased after training Φt=-17.479 to -3.726 ， P<0.05 ）.The covariance analysis showed that individual hypoxia tolerance significantly affected cortisol，testosterone，and their metabolites （ F=3.173 to 9.638， P<0.05 ）；compared withthegoodandqualified groups，theexcelentgroupshowed significantly greaterchanges incortisol，testosterone，and their metabolites after training ⋅P<0.05 ）；and among all the indicators，the changes in An，Etio，and ET in the excellent group were more prominentConclusionThesecretionofsteroid hormones isafectedbyindividualhypoxiatoleranceabilityUrinary An，Etio，andEareotetialoveietandimeatessessmntiicatorforteoiatoleanceofflghtprsoelatig altitudes.

[Key words]hypoxia；androgens；aviation；pilots

急性高空低氧严重威胁飞行安全]，低氧有效意识时间可反映个体耐低氧能力，是急性高空低氧耐力模拟训练中常用的检测指标，但由于场地、设备等限制，无法在执行飞行任务前对飞行人员低氧耐力进行即时评估，因此亟需开发便捷、敏感的即时低氧耐受能力评估指标。（剩余5720字）