基于网络药理学和分子对接探讨天花粉治疗糖尿病作用机制

打开文本图片集

[关键词] 糖尿病；天花粉；网络药理学；分子对接；过氧化物酶体增殖物激活受体[中图分类号] R587.1;R285.5 [文献标志码］A [文章编号] 2096-5532（2025）03-0381-06doi：10.11712/jms.2096-5532.2025.61.104 [开放科学（资源服务）标识码（OSID）][网络出版]https：//link.cnki.net/urlid/37.1517.R.20250731.1031.003; 2025-07-3113：05：36

Mechanism of actionofRadixTrichosanthis intreatment of diabetesmelitus：Astudybasedonnetwork pharmacologyand molecular docking ZHANG Lei， CAO Yang，WANG Xiaoping ， HE KanLiang， YUAN Qiuzhen，LI Ting（Department of Pharmacy， Shanxi Provincial Hospital of Chinese Medicine，Xi'an 7looo3，China）

[Abstract]ObjectiveToinvestigatethemechanismofactionofRadixTrichosanthisinthetreatmentof diabetesmellitus based on network pharmacologyand moleculardocking.MethodsTCMSPdatabase was used toobtain theffectiveconstituents of Radix Trichosanthis，nd SwissTargetPredictiondataplatform wasusedtoobtainthecoresponding targets.MalaCardsdatabase wasusedtoobtainthetargetsasociatedwithdiabetesmelltus.Thecommontargetsofthedrugandthediseasewereobtained，and then STRING database and Cytoscape software wereused toconstruct a protein-proteininteraction（PPI）network andidentifythe coretargets.Matescape database was usedto perform the gene ontology（GO）and Kyoto Encyclopedia of Genes and Genomes （KEGG）analyses.Autodock Vina wasusedtoperformmoleculardockingbetweenthecoretargetsandthecorespondingeffective constituents.ResultsAtotalof28targets wereobtainedforRadixTrichosanthisinthetreatmentofdiabetesmelitus，and10 keytargets wereobtained bytopologicalanalysis.TheKEGG pathwayenrichmentanalysisobtainedthesignaling pathways including the peroxisome proliferator-activated receptor（PPAR）signaling pathway.Moleculardocking showed thatthecompounds in Radix Trichosanthis hadgood binding activitytothetargets in thePPAR signaling pathway.ConclusionRadix Trichosanthis may exert a regulatory effect on diabetes mellitus through the PPAR signaling pathway.

[Key words]diabetes melitus；Trichosanthis Radix;network pharmacology；molecular docking simulation；peroxisome proliferator-activated receptors

糖尿病是一种慢性代谢性疾病，其特征是病人的血糖长期高于标准值。（剩余8404字）